Compound

15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

An icosanoid anion that is the conjugate base of 15-HETE, obtained by deprotonation of the carboxy group; major species at pH 7.3.

Definition from ChEBI (CHEBI:78832), read 2026-09-23. CC BY 4.0.

CHEBI:78832ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C20H31O3
Mass: 319.465 g/mol
Charge: -1
InChIKey: JSFATNQSLKRBCI-USWFWKISSA-M
SMILES: CCCCCC(O)/C=C/C=CC/C=CC/C=CCCCC(=O)[O-]
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

12 entities

12 entities reached.

0 reported hops12 assembled from the scaffold

What the reference databases state

Statements

14 statements

14 statements · 1 reference database · Subject: 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate · Sources: Rhea

Order

15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is converted to 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoACompoundRhea RHEA:52116Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is converted to 15-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoateCompoundRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by CYP4F11ProteinRhea RHEA:78611Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by UGT1A1ProteinRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by UGT1A10ProteinRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by UGT1A4ProteinRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by UGT1A6ProteinRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by UGT1A9ProteinRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is metabolised by UGT2B7ProteinRhea RHEA:79919Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of ACSL1ProteinRhea RHEA:52116Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of ACSL3ProteinRhea RHEA:52116Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of ACSL4ProteinRhea RHEA:52116Inferred only

Show the remaining 2

15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of ACSL5ProteinRhea RHEA:52116Inferred only
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate is a substrate of ACSL6ProteinRhea RHEA:52116Inferred only

Reactions

4 reactions

15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+ATP(4-)+coenzyme A(4-)15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl-CoA+AMP+diphosphate(3-)
Catalysed by ACSL4 or ACSL3 or ACSL1 or ACSL6 or ACSL5
Reaction pageLeft to rightBalanced
Rhea RHEA:52116CC BY 4.0Reference data
1-octadecanoyl-2-(15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine+water1-octadecanoyl-sn-glycero-3-phosphoethanolamine+15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+hydron
Catalysed by PLA2G6
Reaction pageLeft to rightBalanced
Rhea RHEA:63256CC BY 4.0Reference data
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+reduced [NADPH--hemoprotein reductase]+dioxygenCHEBI:229486+oxidized [NADPH--hemoprotein reductase]+water+hydron
Catalysed by CYP4F11
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:78611CC BY 4.0Reference data
15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+UDP-alpha-D-glucuronate15-O-(beta-D-glucuronosyl)-(5Z,8Z,11Z,14Z)-eicosatetraenoate+UDP+hydron
Catalysed by UGT1A9 or UGT2B7 or UGT1A6 or UGT1A1 or UGT1A4 or UGT1A10
Reaction pageLeft to rightBalanced
Rhea RHEA:79919CC BY 4.0Reference data

Other names

5 names

Resolves to: 15-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate

Also called: (5Z,8Z,11Z,13E)-15-hydroxyeicosatetraenoate(5Z,8Z,11Z,13E)-15-hydroxyicosatetraenoate15-HETE(1-)15-HETE(1−)
Systematic name: (5Z,8Z,11Z,13E)-15-hydroxyicosa-5,8,11,13-tetraenoate