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Proteins/UNIPROT:Q13183
Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule. Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic. Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood. Has a critical role in renal dicarboxylate transport (By similarity)..
Function from UniProtKB (Q13183), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · transported by
1 compound
1 compound.
0 reported routes1 assembled route
27 statements
27 statements · 6 reference databases · Subject: SLC13A2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
8 reactions
2sodium(1+)+succinate(2-)2sodium(1+)+succinate(2-)
Transported by SLC13A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04939CC BY 4.0Reference data
citric acid+sodium(1+)citric acid+sodium(1+)
Transported by SLC13A2 or SLC13A5
Reaction pageLeft to right
5 names
Resolves to: SLC13A2
Human-GEM MAR05994CC BY 4.0Reference data
citric acid+2sodium(1+)citric acid+2sodium(1+)
Transported by SLC13A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05995CC BY 4.0Reference data
sodium(1+)+succinate(2-)sodium(1+)+succinate(2-)
Transported by SLC13A2
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR09610CC BY 4.0Reference data
succinate(2-)+3sodium(1+)succinate(2-)+3sodium(1+)
Transported by SLC13A2 or SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71919CC BY 4.0Reference data
fumaric acid+3sodium(1+)fumaric acid+3sodium(1+)
Transported by SLC13A2 or SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71931CC BY 4.0Reference data
2-oxoglutarate(2-)+3sodium(1+)2-oxoglutarate(2-)+3sodium(1+)
Transported by SLC13A2 or SLC13A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:71939CC BY 4.0Reference data
citric acid+3sodium(1+)citric acid+3sodium(1+)
Transported by SLC13A2
Reaction pageDirection not assertedBalanced
Rhea RHEA:72195CC BY 4.0Reference data