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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q01344

IL5RA

Protein·UNIPROT:Q01344

Open in the graph

Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway..

Function from UniProtKB (Q01344), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

30 statements

30 statements · 4 reference databases · Subject: IL5RA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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IL5RA covaries with AADACProteinHetionet hetionet:covaries:13-3568Inferred only
IL5RA covaries with C12orf71ProteinHetionet hetionet:covaries:3568-728858Inferred only
IL5RA covaries with FCARProteinHetionet hetionet:covaries:2204-3568Inferred only
IL5RA covaries with GALNT9ProteinHetionet hetionet:covaries:3568-50614Inferred only
IL5RA covaries with NADKProteinHetionet hetionet:covaries:3568-65220Inferred only
CSF2RB interacts with IL5RAProteinHetionet hetionet:interacts:1439-3568Inferred only
GRB2 interacts with IL5RAProteinHetionet hetionet:interacts:2885-3568Inferred only
IL5 interacts with IL5RAProteinHetionet hetionet:interacts:3567-3568Inferred only
IL5RA interacts with JAK1ProteinHetionet hetionet:interacts:3568-3716Inferred only
IL5RA interacts with JAK2ProteinHetionet hetionet:interacts:3568-3717Inferred only
IL5RA interacts with SDCBPProteinHetionet hetionet:interacts:3568-6386Inferred only
IL5RA interacts with UNC119ProteinHetionet hetionet:interacts:3568-9094Inferred only

Show the remaining 18

IL5RA participates in Cancer pathwaysPathwayWikiPathways WP5434Inferred only
IL5RA participates in Cytokine cytokine receptor interactionPathwayWikiPathways WP5473Inferred only
IL5RA participates in Cytokine Signaling in Immune systemPathwayReactome R-HSA-1280215Inferred only
IL5RA participates in IL3 signalingPathwayWikiPathways WP286Inferred only
IL5RA participates in IL5 signalingPathwayWikiPathways WP127Inferred only
IL5RA participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
IL5RA participates in Inflammatory response pathwayPathwayWikiPathways WP453Inferred only
IL5RA participates in Interleukin receptor SHC signalingPathwayReactome R-HSA-912526Inferred only
IL5RA participates in Interleukin-2 family signalingPathwayReactome R-HSA-451927Inferred only
IL5RA participates in Interleukin-3, Interleukin-5 and GM-CSF signalingPathwayReactome R-HSA-512988Inferred only
IL5RA participates in MAPK family signaling cascadesPathwayReactome R-HSA-5683057Inferred only
IL5RA participates in MAPK1/MAPK3 signalingPathwayReactome R-HSA-5684996Inferred only
IL5RA participates in RAF/MAP kinase cascadePathwayReactome R-HSA-5673001Inferred only
IL5RA participates in Regulatory circuits of STAT3 signalingPathwayWikiPathways WP4538Inferred only
IL5RA participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
IL5RA participates in Signaling by InterleukinsPathwayReactome R-HSA-449147Inferred only
IL5RA regulates positive regulation of cell population proliferationBiological processgene ontology Q01344|GO:0008284Inferred only
IL5RA regulates positive regulation of leukocyte proliferationBiological processgene ontology Q01344|GO:0070665Inferred only

Other names

7 names

Resolves to: IL5RA

Also called: CD antigen CD125CDw125IL-5 receptor subunit alphaIL-5R subunit alphaIL-5R-alphaIL-5RAIL5R

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