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Proteins/UNIPROT:Q96JA3
Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane, playing a pivotal role in the synthesis of complex glycosphingolipids; binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for this GlcCer transfer ability. Also functions as a cargo transport protein required for apical transport from the Golgi complex, including transport of AQP2 from the TGN to sites of AQP2 phosphorylation. Additionally required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation (By similarity)..
Function from UniProtKB (Q96JA3), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
20 statements
20 statements · 3 reference databases · Subject: PLEKHA8 · Sources: Hetionet, Reactome, Rhea
2 reactions
a beta-D-glucosyl-(1<->1')-N-acylsphing-4-eninea beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine
Transported by PLEKHA8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:77259CC BY 4.0Reference data
beta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-eninebeta-D-glucosyl-(1<->1)-N-octadecanoylsphing-4-enine
Transported by PLEKHA8
Reaction pageDirection not assertedBalanced
Rhea RHEA:77263CC BY 4.0Reference data
7 names
Resolves to: PLEKHA8