Proteins/UNIPROT:O75487

GPC4

ProteinUNIPROT:O75487

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity)..

Function from UniProtKB (O75487), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

Keipert syndrome has a germline basis in GPC4DiseaseGenCC HGNC:4452|MONDO:0009720Inferred only

Statements

51 statements

51 statements · 4 reference databases · Subject: GPC4 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ACP5 interacts with GPC4ProteinHetionet hetionet:interacts:2239-54Inferred only
CCNC interacts with GPC4ProteinHetionet hetionet:interacts:2239-892Inferred only
GPC4 interacts with COL18A1ProteinHetionet hetionet:interacts:2239-80781Inferred only
GPC4 interacts with FGF2ProteinHetionet hetionet:interacts:2239-2247Inferred only
GPC4 interacts with IQCB1ProteinHetionet hetionet:interacts:2239-9657Inferred only
GPC4 participates in Attachment and EntryPathwayReactome R-HSA-9694614Inferred only
GPC4 participates in Coagulation pathwayPathwayReactome R-HSA-9769740Inferred only
GPC4 participates in Defective B3GALT6 causes EDSP2 and SEMDJL1PathwayReactome R-HSA-4420332Inferred only
GPC4 participates in Defective B3GAT3 causes JDSSDHDPathwayReactome R-HSA-3560801Inferred only
GPC4 participates in Defective B4GALT7 causes EDS, progeroid typePathwayReactome R-HSA-3560783Inferred only
GPC4 participates in Defective EXT1 causes exostoses 1, TRPS2 and CHDSPathwayReactome R-HSA-3656253Inferred only
GPC4 participates in Defective EXT2 causes exostoses 2PathwayReactome R-HSA-3656237Inferred only

Show the remaining 39

GPC4 participates in Dengue Virus Attachment and EntryPathwayReactome R-HSA-9918485Inferred only
GPC4 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
GPC4 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
GPC4 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
GPC4 participates in Diseases associated with glycosaminoglycan metabolismPathwayReactome R-HSA-3560782Inferred only
GPC4 participates in Diseases of glycosylationPathwayReactome R-HSA-3781865Inferred only
GPC4 participates in Diseases of metabolismPathwayReactome R-HSA-5668914Inferred only
GPC4 participates in Early SARS-CoV-2 Infection EventsPathwayReactome R-HSA-9772572Inferred only
GPC4 participates in Glycosaminoglycan metabolismPathwayReactome R-HSA-1630316Inferred only
GPC4 participates in Glycosaminoglycan-protein linkage region biosynthesisPathwayReactome R-HSA-1971475Inferred only
GPC4 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
GPC4 participates in Heparan sulfate/heparin (HS-GAG) metabolismPathwayReactome R-HSA-1638091Inferred only
GPC4 participates in HS-GAG biosynthesisPathwayReactome R-HSA-2022928Inferred only
GPC4 participates in HS-GAG degradationPathwayReactome R-HSA-2024096Inferred only
GPC4 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
GPC4 participates in Initiation of coagulation cascadePathwayReactome R-HSA-9769735Inferred only
GPC4 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
GPC4 participates in Metabolism of carbohydrates and carbohydrate derivativesPathwayReactome R-HSA-71387Inferred only
GPC4 participates in Metabolism of fat-soluble vitaminsPathwayReactome R-HSA-6806667Inferred only
GPC4 participates in Metabolism of vitamins and cofactorsPathwayReactome R-HSA-196854Inferred only
GPC4 participates in Regulation of clotting cascadePathwayReactome R-HSA-9769739Inferred only
GPC4 participates in Respiratory syncytial virus (RSV) attachment and entryPathwayReactome R-HSA-9820960Inferred only
GPC4 participates in Respiratory Syncytial Virus Infection PathwayPathwayReactome R-HSA-9820952Inferred only
GPC4 participates in Retinoid metabolism and transportPathwayReactome R-HSA-975634Inferred only
GPC4 participates in RSV-host interactionsPathwayReactome R-HSA-9833110Inferred only
GPC4 participates in SARS-CoV InfectionsPathwayReactome R-HSA-9679506Inferred only
GPC4 participates in SARS-CoV-2 InfectionPathwayReactome R-HSA-9694516Inferred only
GPC4 participates in Sensory PerceptionPathwayReactome R-HSA-9709957Inferred only
GPC4 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
GPC4 participates in Visual phototransductionPathwayReactome R-HSA-2187338Inferred only
GPC4 participates in Wnt signalingPathwayWikiPathways WP428Inferred only
GPC4 regulates regulation of neurotransmitter receptor localization to postsynaptic specialization membraneBiological processgene ontology O75487|GO:0098696Inferred only
GPC4 regulates regulation of presynapse assemblyBiological processgene ontology O75487|GO:1905606Inferred only
GPC4 regulates regulation of signal transductionBiological processgene ontology O75487|GO:0009966Inferred only
ARF4 increases the expression of GPC4ProteinHetionet hetionet:regulates:378-2239Inferred only
CLPB increases the expression of GPC4ProteinHetionet hetionet:regulates:81570-2239Inferred only
FAM114A2 increases the expression of GPC4ProteinHetionet hetionet:regulates:10827-2239Inferred only
IL2RB increases the expression of GPC4ProteinHetionet hetionet:regulates:3560-2239Inferred only
SOX2 increases the expression of GPC4ProteinHetionet hetionet:regulates:6657-2239Inferred only

Other names

2 names

Resolves to: GPC4

Also called: Glypican-4K-glypican

← Every protein Find it in the graph →