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Proteins/UNIPROT:Q9Y661
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to the 3-O- position of an N-sulfoglucosamine residue in heparan sulfate. Is able to install the 3-O-sulfo group in a disaccharide domain consisting of -GlcA2S-GlcNS- to form the -GlcA2S-GlcNS3S- sequence, and in -IdoA2S-GlcNS-IdoA2S- to form -IdoA2S-GlcNS3S-IdoA2S-. Does not sulfate the -GlcA-GlcNS-IdoA2S- domain..
Function from UniProtKB (Q9Y661), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
8 statements
8 statements · 3 reference databases · Subject: HS3ST4 · Sources: Hetionet, Reactome, WikiPathways
4 reactions
MAM02085g+3'-phospho-5'-adenylyl sulfateproton+MAM02086g+adenosine 3',5'-bismonophosphate
Catalysed by HS3ST1 or HS3ST4 or HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23Golgi apparatus
Human-GEM MAR07220CC BY 4.0Reference data
MAM02086g+3'-phospho-5'-adenylyl sulfateproton+MAM02087g+adenosine 3',5'-bismonophosphate
5 names
Resolves to: HS3ST4
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23, 2.8.2.29Golgi apparatus
Human-GEM MAR07221CC BY 4.0Reference data
MAM02087g+3'-phospho-5'-adenylyl sulfateproton+MAM02054g+adenosine 3',5'-bismonophosphate
Catalysed by HS3ST1 or HS3ST3B1 or HS3ST3A1 or HS3ST6 or HS3ST4 or HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23, 2.8.2.30Golgi apparatus
Human-GEM MAR07222CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfate3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)+adenosine 3',5'-bisphosphate+hydron
Catalysed by HS3ST1 or HS3ST5 or HS3ST6 or HS3ST2 or HS3ST4 or HS3ST3B1 or HS3ST3A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15461CC BY 4.0Reference data