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Proteins/UNIPROT:O60243
6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. Critical for normal neuronal development where it may play a role in neuron branching. May also play a role in limb development (By similarity). May prefer iduronic acid (By similarity)..
Function from UniProtKB (O60243), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
17 statements
17 statements · 4 reference databases · Subject: HS6ST1 · Sources: Bgee, Hetionet, Reactome, WikiPathways
2 reactions
MAM02084g+33'-phospho-5'-adenylyl sulfate3proton+MAM02085g+3adenosine 3',5'-bismonophosphate
Catalysed by HS6ST1 or HS6ST2 or HS6ST3
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.-Golgi apparatus
Human-GEM MAR07219CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfate6-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)+
2 names
Resolves to: HS6ST1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:56604CC BY 4.0Reference data