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Proteins/UNIPROT:Q8IZT8
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry..
Function from UniProtKB (Q8IZT8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
8 statements
8 statements · 3 reference databases · Subject: HS3ST5 · Sources: gene ontology, Reactome, WikiPathways
4 reactions
MAM02085g+3'-phospho-5'-adenylyl sulfateproton+MAM02086g+adenosine 3',5'-bismonophosphate
Catalysed by HS3ST1 or HS3ST4 or HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23Golgi apparatus
Human-GEM MAR07220CC BY 4.0Reference data
MAM02086g+3'-phospho-5'-adenylyl sulfateproton+MAM02087g+adenosine 3',5'-bismonophosphate
6 names
Resolves to: HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23, 2.8.2.29Golgi apparatus
Human-GEM MAR07221CC BY 4.0Reference data
MAM02087g+3'-phospho-5'-adenylyl sulfateproton+MAM02054g+adenosine 3',5'-bismonophosphate
Catalysed by HS3ST1 or HS3ST3B1 or HS3ST3A1 or HS3ST6 or HS3ST4 or HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23, 2.8.2.30Golgi apparatus
Human-GEM MAR07222CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfate3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)+adenosine 3',5'-bisphosphate+hydron
Catalysed by HS3ST1 or HS3ST5 or HS3ST6 or HS3ST2 or HS3ST4 or HS3ST3B1 or HS3ST3A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15461CC BY 4.0Reference data