Loading the page.
Proteins/UNIPROT:O14792
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site..
Function from UniProtKB (O14792), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
18 statements
18 statements · 4 reference databases · Subject: HS3ST1 · Sources: Bgee, Hetionet, Reactome, WikiPathways
3 reactions
MAM02085g+3'-phospho-5'-adenylyl sulfateproton+MAM02086g+adenosine 3',5'-bismonophosphate
Catalysed by HS3ST1 or HS3ST4 or HS3ST5
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23Golgi apparatus
Human-GEM MAR07220CC BY 4.0Reference data
MAM02087g+3'-phospho-5'-adenylyl sulfateproton+MAM02054g+adenosine 3',5'-bismonophosphate
6 names
Resolves to: HS3ST1
Reaction pageLeft to rightBalance undeterminableEC 2.8.2.23, 2.8.2.30Golgi apparatus
Human-GEM MAR07222CC BY 4.0Reference data
alpha-D-glucosaminyl-[heparan sulfate](n)+3'-phosphoadenylyl sulfate3-sulfo-alpha-D-glucosaminyl-[heparan sulfate](n)+adenosine 3',5'-bisphosphate+hydron
Catalysed by HS3ST1 or HS3ST5 or HS3ST6 or HS3ST2 or HS3ST4 or HS3ST3B1 or HS3ST3A1
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15461CC BY 4.0Reference data