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Proteins/UNIPROT:O43909
Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Initiates HS synthesis by transferring the first N-acetyl-alpha-D-glucosamine (alpha-GlcNAc) residue (GlcNAcT-I activity) to the tetrasaccharide linker (GlcA-Gal-Gal-Xyl-)Ser core linker. May also transfer alpha-GlcNAc residues during HS elongation (GlcNAcT-II activity). Lacks glucuronyl transferase II (GlcAT-II) activity. Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs). Through the synthesis of HS, regulates postnatal pancreatic islet maturation and insulin secretion (By similarity)..
Receptor for REG3A, REG3B and REG3G, induces the activation of downstream signaling pathways such as PI3K-AKT or RAS-RAF-MEK-ERK signaling pathway. Required for the function of REG3A in regulating keratinocyte proliferation and differentiation. Required for the inhibition of skin inflammation mediated by REG3A through the activation of PI3K-AKT-STAT3 pathway. Required for the function of REG3A and REG3G in glucose tolerance in pancreas. Expressed in microglia, is activated by nociceptor-derived REG3G in response to endotoxins, leading to the inhibition of kynurenine pathway to prevent endotoxic death (By similarity)..
Function from UniProtKB (O43909), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
70 statements
70 statements · 7 reference databases · Subject: EXTL3 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
MAM00762g+CHEBI:16264proton+MAM02081g+UDP
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.223Golgi apparatus
Human-GEM MAR07207CC BY 4.0Reference data
MAM02088g+CHEBI:16264proton+MAM02089g+UDP
8 names
Resolves to: EXTL3
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Golgi apparatus
Human-GEM MAR07209CC BY 4.0Reference data
MAM02090g+CHEBI:16264proton+MAM02091g+UDP
Catalysed by EXT1 & EXT2 or EXTL3 or EXTL1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Golgi apparatus
Human-GEM MAR07211CC BY 4.0Reference data
MAM02092g+CHEBI:16264proton+MAM02093g+UDP
Catalysed by EXT1 & EXT2 or EXTL3 or EXTL1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Golgi apparatus
Human-GEM MAR07213CC BY 4.0Reference data
MAM02094g+CHEBI:16264proton+MAM02095g+UDP
Catalysed by EXT1 & EXT2 or EXTL3 or EXTL1
Reaction pageLeft to rightBalance undeterminableEC 2.4.1.223, 2.4.1.224, 2.4.1.225Golgi apparatus
Human-GEM MAR07215CC BY 4.0Reference data
3-O-(beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP-N-acetyl-alpha-D-glucosamine3-O-(alpha-D-GlcNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein]+UDP+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:16221CC BY 4.0Reference data