a ganglioside GD2 (d18:1(4E))

Three steps

• (7Z)-hexadecenoyl-CoAReach from here →
  1. Hexosaminidase A, Lysosomal
  2. solute carrier (acetyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by HEXA, HEXB, SLC33A1, SLC27A2 and 7 morelysosome, cytosolOne of 8 routes

• a ganglioside GD1c (d18:1(4E))Reach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GM1b (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c (d18:1(4E)) + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA5, ST8SIA6 and 1 moreextracellular space, nucleus

• a ganglioside GQ1c (d18:1(4E))Reach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GT1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1c (d18:1(4E)) + CMP + H(+)

  Catalysed by NEU3, CMAS, ST3GAL4extracellular space, nucleus

• a ganglioside GP1c (d18:1(4E))Reach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GQ1c (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = a ganglioside GP1c (d18:1(4E)) + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA5extracellular space, nucleus

• N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enineReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminosyl-(2->6)]-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine + CMP + H(+)

  Catalysed by NEU3, CMAS, ST6GALNAC6, ST6GALNAC5extracellular space, nucleus

• tricosanoyl-CoAReach from here →
  1. Hexosaminidase A, Lysosomal
  2. solute carrier (acetyl-CoA)
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by HEXA, HEXB, SLC33A1, SLC27A2 and 7 morelysosome, cytosolOne of 4 routes

• a ganglioside GM1bReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GA1 + CMP-N-acetyl-beta-neuraminate = a ganglioside GM1b + CMP + H(+)

  Catalysed by NEU3, CMAS, ST3GAL1, ST3GAL2extracellular space, nucleus

• ganglioside GD1a (18:1(4E)/18:0)Reach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. ganglioside GM1 (d18:1(4E)/18:0) + CMP-N-acetyl-beta-neuraminate = ganglioside GD1a (18:1(4E)/18:0) + CMP + H(+)

  Catalysed by NEU3, CMAS, ST3GAL1, ST3GAL2extracellular space, nucleus

• a neolactoside IV(3)-alpha-NeuAc-nLc4CerReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a neolactoside nLc4Cer + CMP-N-acetyl-beta-neuraminate = a neolactoside IV(3)-alpha-NeuAc-nLc4Cer + CMP + H(+)

  Catalysed by NEU3, CMAS, ST3GAL4extracellular space, nucleus

• a ganglioside GT1aReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GD1a + CMP-N-acetyl-beta-neuraminate = a ganglioside GT1a + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA6extracellular space, nucleus

• a ganglioside GD1cReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GM1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GD1c + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA6extracellular space, nucleus

• an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enineReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GM4 (d18:1(4E)) + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA6extracellular space, nucleus

• N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramideReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide + CMP-N-acetyl-beta-neuraminate = N-acetyl-alpha-neuraminosyl-(2->8)-N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1<->1')-ceramide + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA6extracellular space, nucleus

• a ganglioside GQ1bReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. CTP:N-acetylneuraminate cytidylyltransferase
  3. a ganglioside GT1b + CMP-N-acetyl-beta-neuraminate = a ganglioside GQ1b + CMP + H(+)

  Catalysed by NEU3, CMAS, ST8SIA6extracellular space, nucleus

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. Sialidase, Plasma Membrane (Neu3)
  2. N-Acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by NEU3, NPL, PDHA1, PDHB and 1 moreextracellular space, cytosol, mitochondrial matrix