a ganglioside GT3 (d18:1(4E))

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

556 compounds within 3 steps: 1 in 1, 109 in 2, 446 in 3

Three steps

(2E,8Z,11Z,14Z)-eicosatetraenoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
3. ELOVL fatty acid elongase (trans-2-cis,cis,cis-8,11,14-eicosatetraenoyl-CoA)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol, endoplasmic reticulumOne of 2 routes
3-oxo-(11Z)-octadecenoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
3-oxo-(13Z)-eicosenoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
Catalysed by SLC33A1, CPT1A, CPT1C, CPT1B and 1 morecytosol
1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
O-dodecanoyl-R-carnitineReach from here →
1. solute carrier (acetyl-CoA)
2. Carnitine O-Palmitoyltransferase
3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
Catalysed by SLC33A1, CPT1A, CPT1C, CPT1BcytosolOne of 11 routes
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(11Z,14Z)-eicosadienoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)
3. (11Z,14Z)-eicosadienoyl-CoA hydrolase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 8 morecytosol
(17Z)-hexacosenoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (ximenic acid)
3. Hexacosenoyl-CoA hydrolase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (DPA)
3. (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA hydrolase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (adrenic acid)
3. (7Z,10Z,13Z,16Z)-docosatetraenoyl-CoA hydrolase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosolOne of 2 routes
2,6,10,14-tetramethylpentadecanoateReach from here →
1. solute carrier (acetyl-CoA)
2. fatty-acid-CoA ligase
3. peroxisomal acyl-CoA thioesterase
Catalysed by SLC33A1, SLC27A2, ACOT2cytosol, peroxisomeOne of 2 routes
a 1,3-diacyl-sn-glycerolReach from here →
1. solute carrier (acetyl-CoA)
2. acyl-CoA:sphingosine N-acyltransferase
3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA
Catalysed by SLC33A1, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatusOne of 2 routes
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
1. solute carrier (acetyl-CoA)
2. acyl-CoA:sphingosine N-acyltransferase
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC33A1, ASAH1, ACER2, ACER1 and 3 morecytosol, Golgi apparatus
a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
1. solute carrier (acetyl-CoA)
2. acyl-CoA:sphingosine N-acyltransferase
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SLC33A1, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus
1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. solute carrier (acetyl-CoA)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octanoyl-CoA = 1-O-(1Z)-alkenyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SLC33A1, CROT, LPCAT4cytosol, mitochondrial matrix
1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
tetracosan-1-olReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. tetracosanoyl-CoA + 2 NADPH + 2 H(+) = tetracosan-1-ol + 2 NADP(+) + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(2E,9Z)-hexadecadienoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. medium-chain acyl-CoA dehydrogenase (palmitoleoyl-CoA)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 9 morecytosol, mitochondrial matrixOne of 3 routes
trans-2-heptadecenoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (margaric acid)
3. medium-chain acyl-CoA dehydrogenase (heptadecanoyl-CoA)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 9 morecytosol, mitochondrial matrixOne of 2 routes
(2E,9Z)-octadecadienoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. Transport of octadecenoyl-CoA into Mitochondrial Matrix
3. medium-chain acyl-CoA dehydrogenase (oleoyl-CoA)
Catalysed by SLC33A1, CPT1A, CPT1C, CPT1B and 4 morecytosol, mitochondrial matrixOne of 2 routes
(2E,9Z,12Z)-octadecatrienoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + oxidized [electron-transfer flavoprotein] + H(+) = (2E,9Z,12Z)-octadecatrienoyl-CoA + reduced [electron-transfer flavoprotein]
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 8 morecytosol
(2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoAReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + O2 = (2E,4Z,7Z,10Z,13Z,16Z,19Z)-docosaheptaenoyl-CoA + H2O2
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
N-(9Z-octadecenoyl)-sphing-4-enineReach from here →
1. solute carrier (acetyl-CoA)
2. acyl-CoA:sphingosine N-acyltransferase
3. N-(9Z-octadecenoyl)-sphing-4-enine + H2O = sphing-4-enine + (9Z)-octadecenoate
Catalysed by SLC33A1, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus
9-cis-retinolReach from here →
1. solute carrier (acetyl-CoA)
2. Palmitoyl-CoA:retinol O-acyltransferase
3. 11-cis-retinol = 9-cis-retinol
Catalysed by SLC33A1, DGAT1, LRAT, AWAT1 and 3 morecytosol
tricosanoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (tricosanoic acid)
3. Tricosanoyl-CoA hydrolase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
thio-Mo-molybdopterinReach from here →
1. solute carrier (acetyl-CoA)
2. N-acetylglutamate synthase (N-acetyl-L-cysteine)
3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O
Catalysed by SLC33A1, NAGS, MOCOScytosol, mitochondrial matrix
cholesteryl octadecanoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol, endoplasmic reticulumOne of 2 routes
N-octadecanoylhexadecasphinganineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. hexadecasphinganine + octadecanoyl-CoA = N-octadecanoylhexadecasphinganine + CoA + H(+)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
glycodeoxycholateReach from here →
1. solute carrier (acetyl-CoA)
2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
3. deoxycholoyl-CoA to glycodeoxycholate conversion
Catalysed by SLC33A1, SLC27A2, SLC27A5cytosolOne of 3 routes
sphinga-4E,14Z-dienineReach from here →
1. solute carrier (acetyl-CoA)
2. acyl-CoA:sphingosine N-acyltransferase
3. sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by SLC33A1, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus
1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
cholesteryl (9Z)-hexadecenoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (linolenate)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
cholesteryl (8Z,11Z,14Z)-eicosatrienoateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (dihomo-gamma-linolenate)
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, endoplasmic reticulum
O-tetradecanoyl-(R)-carnitineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
O-octadecanoyl-(R)-carnitineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
O-eicosanoyl-(R)-carnitineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
1. solute carrier (acetyl-CoA)
2. Carnitine O-Palmitoyltransferase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by SLC33A1, CPT1A, CPT1C, CPT1B and 2 morecytosol, peroxisomeOne of 7 routes
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (EPA)
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, endoplasmic reticulumOne of 2 routes
N-tetradecanoylglycineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes
N-eicosanoylglycinateReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes
N-docosanoylglycineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (behenic acid)
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes
N-hexacosanoylglycineReach from here →
1. solute carrier (acetyl-CoA)
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by SLC33A1, SLC27A2, ACSL4, ACSL3 and 6 morecytosolOne of 2 routes