(11Z,14Z)-eicosadienoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

656 compounds within 3 steps: 4 in 1, 144 in 2, 508 in 3

Three steps

1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosol
1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + a 1-acyl-sn-glycero-3-phosphocholine = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by FADS2, FADS1, LPCAT3
1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a 1-acyl-sn-glycero-3-phospho-L-serine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by FADS2, FADS1, LPCAT3
1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. a 1-acyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by FADS2, FADS1, LPCAT4, LPCAT3
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
3. nonadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 10 morecytosol
1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 4 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosol
1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = a 1-acyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by FADS2, FADS1, MBOAT7, AGPAT3
1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-O-octadecyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-O-octadecyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by FADS2, FADS1, LPCAT2
1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by BAAT, ACOT6, ACOT1, CROT and 1 morecytosol, mitochondrial matrix
1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-acyl-2-octadecanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 7 morecytosol
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-octadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by FADS2, FADS1, LPCAT4
1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. medium-chain acyl-CoA ligase (decanoic acid)
3. decanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-decanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by BAAT, ACOT6, ACOT1, ACSM4 and 6 morecytosol
1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. octanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-octanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by BAAT, ACOT6, ACOT1, CROT and 1 morecytosol, mitochondrial matrix
1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-tetradecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-dodecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 2-(9Z-octadecenoyl)-glycerol + dodecanoyl-CoA = 1-dodecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 9 morecytosol
1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 2-(9Z-octadecenoyl)-glycerol + tetradecanoyl-CoA = 1-tetradecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 9 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-glycerol + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 2-(9Z-octadecenoyl)-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by FADS2, FADS1, MOGAT2, MOGAT1
1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 2-(9Z-octadecenoyl)-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z,12Z-octadecadienoyl)-2-(9Z-octadecenoyl)-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 9 morecytosol
eicosan-1-olReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 2 NADPH + 2 H(+) = eicosan-1-ol + 2 NADP(+) + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 9 morecytosol
hexadecyl (9Z)-hexadecenoateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. hexadecan-1-ol + (9Z)-hexadecenoyl-CoA = hexadecyl (9Z)-hexadecenoate + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 9 morecytosol
hexadecyl octadecanoateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. hexadecan-1-ol + octadecanoyl-CoA = hexadecyl octadecanoate + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-octanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, CROT and 1 morecytosol, mitochondrial matrix
1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octanoyl-CoA = 1'-[1-acyl-2-octanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by BAAT, ACOT6, ACOT1, CROT and 1 morecytosol, mitochondrial matrix
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by FADS2, FADS1, LCLAT1
1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1'-[1-acyl-2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by FADS2, FADS1, LCLAT1
hexadecanedioateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Production of Hexadecanedioylcarnitine
3. hexadecanedioyl-CoA + H2O = hexadecanedioate + CoA + H(+)
Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 3 morecytosol
2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. acyl-CoA pool formation and breakdown
2. 1-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
3. a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + H2O = 2-acyl-sn-glycero-3-phospho-(1'-sn-glycerol) + a fatty acid + H(+)
Catalysed by LCLAT1, LPCAT1, GPAM, PLA2G15 and 1 morecytosolOne of 2 routes
3-oxo-(11Z)-octadecenoyl-CoAReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z)-octadecenoyl-CoA + CO2 + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 9 morecytosol
3-oxo-(13Z)-eicosenoyl-CoAReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-eicosenoyl-CoA + CO2 + CoA
Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 3 morecytosol
1-O-alkyl-2,3-diacyl-sn-glycerolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. 1-O-alkyl-2-acyl-sn-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-alkyl-2,3-diacyl-sn-glycerol + a 2-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15cytosolOne of 2 routes
1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-(9Z-octadecenoyl)-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol)Reach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1'-sn-glycerol) + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
O-dodecanoyl-R-carnitineReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. Carnitine O-Palmitoyltransferase
3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)
Catalysed by BAAT, ACOT6, ACOT1, CPT1A and 2 morecytosolOne of 11 routes
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
3. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by FADS2, FADS1, AGPAT3
1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-octadecanoyl-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-octadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphate + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (DHA)
3. 1-octadecanoyl-sn-glycero-3-phosphate + (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 8 morecytosol
(17Z)-hexacosenoateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by BAAT, ACOT6, ACOT1cytosol, extracellular spaceOne of 13 routes
(7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by BAAT, ACOT6, ACOT1cytosol, extracellular spaceOne of 13 routes
(7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. (10Z)-heptadecenoic acid formation
3. (10Z)-heptadecenoic acid formation
Catalysed by BAAT, ACOT6, ACOT1cytosol, extracellular spaceOne of 14 routes
2,6,10,14-tetramethylpentadecanoateReach from here →
1. (11Z,14Z)-eicosadienoyl-CoA hydrolase
2. fatty-acid-CoA ligase
3. peroxisomal acyl-CoA thioesterase
Catalysed by BAAT, ACOT6, ACOT1, SLC27A2 and 1 morecytosol, peroxisomeOne of 2 routes