(8Z,11Z,14Z)-eicosatrienoyl-CoA

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

741 compounds within 3 steps: 8 in 1, 179 in 2, 554 in 3

Three steps

N-octadecanoylhexadecasphinganineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. hexadecasphinganine + octadecanoyl-CoA = N-octadecanoylhexadecasphinganine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphateReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphate = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
glycodeoxycholateReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. cholate-CoA ligase (3alpha,12alpha-dihydroxy-5beta-cholanate)
3. deoxycholoyl-CoA to glycodeoxycholate conversion
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 3 morecytosolOne of 3 routes
(12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (12R)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
sphinga-4E,14Z-dienineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. acyl-CoA:sphingosine N-acyltransferase
3. sphing-4-enine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = sphinga-4E,14Z-dienine + 2 Fe(III)-[cytochrome b5] + 2 H2O
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, Golgi apparatus
1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerolReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1',3'-bis-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. a 1-acyl-sn-glycero-3-phospho-(1D-myo-inositol) + octadecanoyl-CoA = a 1-acyl-2-octadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosol
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoateReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. unspecific monooxygenase (arachidonate)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 29 morecytosolOne of 4 routes
8,9-epoxy-(5Z,11Z,14Z)-eicosatrienoateReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. unspecific monooxygenase (arachidonate)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 28 morecytosolOne of 3 routes
cholesteryl (9Z)-hexadecenoateReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + cholesterol = cholesteryl (9Z)-hexadecenoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
(9Z,12Z,15Z-octadecatrienoyl)-cholesterolReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (linolenate)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + cholesterol = (9Z,12Z,15Z-octadecatrienoyl)-cholesterol + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserineReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoserine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoserine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
a monoacyl-sn-glycero-3-phosphocholineReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a monoacyl-sn-glycero-3-phosphocholine + a fatty acid + H(+)
Catalysed by LPGAT1, PNLIPRP2cytosol
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphocholine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
2-(acylamino)ethyl fatty acidReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. an N-acylethanolamine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 2-(acylamino)ethyl fatty acid + a 2-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15cytosolOne of 2 routes
1-O-acyl-N-(acetyl)-sphing-4-enineReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. N-(acetyl)-sphing-4-enine + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1-O-acyl-N-(acetyl)-sphing-4-enine + a 1-acyl-sn-glycero-3-phosphocholine
Catalysed by LPGAT1, PLA2G15cytosolOne of 8 routes
1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. 1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = 1-heptadecanoyl-sn-glycero-3-phosphoethanolamine + (5Z,8Z,11Z,14Z)-eicosatetraenoate + H(+)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
O-tetradecanoyl-(R)-carnitineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + (R)-carnitine = O-tetradecanoyl-(R)-carnitine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
O-octadecanoyl-(R)-carnitineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. (R)-carnitine + octadecanoyl-CoA = O-octadecanoyl-(R)-carnitine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosol
O-eicosanoyl-(R)-carnitineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosol
O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Carnitine O-Palmitoyltransferase
3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 6 morecytosol, peroxisomeOne of 7 routes
1,2-diacyl-sn-glycero-3-phosphoethanolReach from here →
1. acyl-CoA pool formation and breakdown
2. a 2-acyl-sn-glycero-3-phosphocholine + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphocholine + CoA
3. ethanol + a 1,2-diacyl-sn-glycero-3-phosphocholine = 1,2-diacyl-sn-glycero-3-phosphoethanol + choline
Catalysed by LPGAT1, PLD1cytosol
1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosol
1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosol
(5Z,8Z,11Z,14Z,17Z-eicosapentaenoyl)-cholesterolReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (EPA)
3. Acyl-CoA:cholesterol O-acyltransferase
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 11 morecytosol, endoplasmic reticulumOne of 7 routes
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine = N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+)
Catalysed by FADS1, LPCAT3, MBOAT7, PLAAT5
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphateReach from here →
1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-octadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
Catalysed by FADS1, AGPAT3, CDS2, CDS1
1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphateReach from here →
1. (8Z,11Z,14Z)-eicosatrienoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O
2. 1-hexadecanoyl-sn-glycero-3-phosphate + (5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CoA
3. 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphate + CTP + H(+) = 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-cytidine-5'-diphosphate + diphosphate
Catalysed by FADS1, AGPAT2, AGPAT3, CDS2 and 1 more
N-tetradecanoylglycineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. tetradecanoyl-CoA + glycine = N-tetradecanoylglycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 10 morecytosolOne of 2 routes
N-eicosanoylglycinateReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 2 routes
N-docosanoylglycineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (behenic acid)
3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 2 routes
N-hexacosanoylglycineReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. hexacosanoyl-CoA + glycine = N-hexacosanoylglycine + CoA + H(+)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 9 morecytosolOne of 2 routes
(2E,5Z)-tetradecadienoyl-CoAReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (physeteric acid)
3. medium-chain acyl-CoA dehydrogenase (5-tetradecenoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol, mitochondrial matrixOne of 4 routes
(2E,7Z)-hexadecadienoyl-CoAReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)
3. medium-chain acyl-CoA dehydrogenase (7-hexadecenoyl-CoA)
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 13 morecytosol, mitochondrial matrixOne of 4 routes
cholesteryl (11Z)-octadecenoateReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + cholesterol = cholesteryl (11Z)-octadecenoate + CoA
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 5 morecytosol
(18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + reduced [NADPH--hemoprotein reductase] + O2 = (18R)-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
prostaglandin H1Reach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. (8Z,11Z,14Z)-eicosatrienoate + 2 O2 = prostaglandin G1
3. prostaglandin G1 + AH2 = prostaglandin H1 + A + H2O
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 2 morecytosol
15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoateReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 15-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
1. fatty acyl-CoA desaturase (N-C20:3CoA -> N-C20:4CoA)
2. Arachidonyl-CoA hydrolase
3. (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = 5-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate
Catalysed by FADS1, ACOT7, BAAT, THEM4 and 3 morecytosol
taurochenodeoxycholateReach from here →
1. Dihomo-gamma-linolenoyl-CoA hydrolase
2. Propanoyl-CoA:acetyl-CoA C-acyltransferase
3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase
Catalysed by ACOT7, BAAT, THEM4, ACOT1 and 4 morecytosol, peroxisomeOne of 5 routes