3-oxohexacosanoyl-CoA

Three steps

• hexanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Activation of adipic acid for Formation of Adipoyl Carnitine

  Catalysed by ACAA1, MYO5B, BAAT, THEM4peroxisome, cytosolOne of 4 routes

• (4Z,7Z,10Z,13Z,16Z)-docosapentaenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((4Z,7Z,10Z,13Z,16Z)-DPA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 8 routes

• (11Z,14Z)-eicosadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((11Z,14Z)-eicosadienoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 6 routes

• 24-hydroxytetracosanoateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. tetracosanoate + reduced [NADPH--hemoprotein reductase] + O2 = 24-hydroxytetracosanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 2 moreperoxisome, cytosol

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 2 moreperoxisome, cytosolOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol

• hexadecanedioyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Production of Hexadecanedioylcarnitine

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosolOne of 2 routes

• pristanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. fatty-acid-CoA ligase

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 1 moreperoxisome, cytosolOne of 2 routes

• a 1,3-diacyl-sn-glycerolReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 3-acyl-sn-glycerol + an acyl-CoA = a 1,3-diacyl-sn-glycerol + CoA

  Catalysed by ACAA1, MYO5B, MOGAT1peroxisome, cytosolOne of 2 routes

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT2, LPCAT1peroxisome, cytosol

• a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + an acyl-CoA = a 1-O-(1Z-alkenyl)-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by ACAA1, MYO5B, LPCAT4peroxisome, cytosol

• undecanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 6 moreperoxisome, cytosolOne of 3 routes

• (2E,9Z)-octadecadienoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxo-hexacosenoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. medium-chain acyl-CoA dehydrogenase (oleoyl-CoA)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 5 moreperoxisome, mitochondrial matrixOne of 2 routes

• 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-eicosanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisome

• O-eicosanoyl-(R)-carnitineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + (R)-carnitine = O-eicosanoyl-(R)-carnitine + CoA

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisome

• (5Z)-tetradecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 9 routes

• (3E)-decenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 4 moreperoxisome, cytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 3 moreperoxisome, cytosol, mitochondrial matrix

• N-eicosanoylglycinateReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Beta Oxidation of Long Chain Fatty Acid
  3. eicosanoyl-CoA + glycine = N-eicosanoylglycinate + CoA + H(+)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisome

• N-docosanoylglycineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Fatty Acid Beta Oxidation (C24->C22), Peroxisomal
  3. docosanoyl-CoA + glycine = N-docosanoylglycine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, HSD17B4, EHHADH and 2 moreperoxisome

• an N(2)-acyl-L-glutamineReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + L-glutamine = an N(2)-acyl-L-glutamine + CoA + H(+)

  Catalysed by ACAA1, MYO5B, GLYATL1B, GLYATL1peroxisome, cytosol

• (7Z)-hexadecenoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (7-palmitoleic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. Tetracosenoyl-CoA hydrolase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by ACAA1, MYO5B, BAAT, THEM4 and 8 moreperoxisome, cytosolOne of 5 routes

• a 3-oxoacyl-CoAReach from here →
  1. acetyl-CoA C-acyltransferase (3-oxohexacosanoyl-CoA)
  2. acyl-CoA pool formation and breakdown
  3. an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA

  Catalysed by ACAA1, MYO5B, SCP2, ACAA2 and 1 moreperoxisome, cytosol