3-aminopropanal

Three steps

• trans-4-hydroxy-L-prolineReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. trans-4-hydroxy-L-proline(out) + L-alanine(in) + Na(+)(out) = trans-4-hydroxy-L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by ALDH2, ALDH1B1, AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinateReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. 1-(5-Phosphoribosyl)-5-amino-4-carboxyimidazole:L-aspartate ligase (ADP-forming)

  Catalysed by ALDH2, ALDH1B1, GADL1, CSAD and 1 moremitochondrial matrix, cytosolOne of 2 routes

• anserineReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. beta-alanine + L-histidine + ATP = carnosine + ADP + phosphate + H(+)
  3. carnosine + S-adenosyl-L-methionine = anserine + S-adenosyl-L-homocysteine + H(+)

  Catalysed by ALDH2, ALDH1B1, CARNS1, CARNMT1mitochondrial matrix

• N(8)-acetylspermidineReach from here →
  1. spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
  2. spermine + O2 + H2O = 3-aminopropanal + spermidine + H2O2
  3. N8-acetylspermidine to spermidine conversion

  Catalysed by SMOXcytosolOne of 3 routes

• 5-amino-2-oxopentanoateReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. beta-alanine + L-arginine = 3-guanidinopropanoate + L-ornithine
  3. L-ornithine + pyruvate = 5-amino-2-oxopentanoate + L-alanine

  Catalysed by ALDH2, ALDH1B1, GATM, AGXT2mitochondrial matrixOne of 2 routes

• 4-aminobutanoateReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. transport of beta-alanine and chloride (cytosol to extracellular)
  3. transport of 4-aminobutyrate and chloride (cytosol to extracellular)

  Catalysed by ALDH2, ALDH1B1, SLC6A6, SLC6A14 and 1 moremitochondrial matrix, extracellular space, cytosolOne of 4 routes

• L-prolineReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. L-proline(out) + L-alanine(in) + Na(+)(out) = L-proline(in) + L-alanine(out) + Na(+)(in)

  Catalysed by ALDH2, ALDH1B1, AGXT2, SLC1A4mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• 3-sulfino-L-alanineReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. L-aspartate + H(+) = beta-alanine + CO2
  3. transport of 3-sulfinoalanine and aspartate (cytosol to mitochondria)

  Catalysed by ALDH2, ALDH1B1, GADL1, CSAD and 2 moremitochondrial matrix, cytosolOne of 4 routes

• L-cysteinylglycineReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. gamma-glutamyltransferase (alanine)

  Catalysed by ALDH2, ALDH1B1, AGXT2, GGTLC3 and 5 moremitochondrial matrix, cytosolOne of 2 routes

• Mo-molybdopterinReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. Mo-molybdopterin + L-cysteine + AH2 = thio-Mo-molybdopterin + L-alanine + A + H2O

  Catalysed by ALDH2, ALDH1B1, AGXT2, MOCOSmitochondrial matrix

• (2S)-2-aminobutanoateReach from here →
  1. Beta-Aminopropion Aldehyde:NAD+ Oxidoreductase, Mitochondrial
  2. 3-oxopropanoate + L-alanine = beta-alanine + pyruvate
  3. 2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

  Catalysed by ALDH2, ALDH1B1, AGXT2mitochondrial matrix