D-glucopyranose 6-phosphate

Three steps

• D-mannose 6-phosphateReach from here →
  1. D-glucose-6-phosphate:NADP+ 1-oxidoreductase
  2. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
  3. D-glucose 6-phosphate = D-mannose 6-phosphate

  Catalysed by G6PD, GPIendoplasmic reticulum

• D-glyceraldehyde 3-phosphateReach from here →
  1. D-glucose-6-phosphate aldose-ketose-isomerase
  2. D-Fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehyde transferase
  3. D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate

  Catalysed by GPI, TKT, TKTL1, TKTL2 and 1 morecytosol

• dTMPReach from here →
  1. D-Glucose-6-phosphate phosphohydrolase
  2. dATP:D-glucose 6-phosphotransferase
  3. deoxythymidylate kinase (dADP)

  Catalysed by G6PC1, G6PC3, G6PC2, HK1 and 4 moreendoplasmic reticulum, cytosol, mitochondrial matrixOne of 2 routes

• 2'-phospho-cyclic ADP-riboseReach from here →
  1. D-glucose-6-phosphate:NADP+ 1-oxidoreductase
  2. NAADP(+) + D-glucose 6-phosphate = NAADPH + 6-phospho-D-glucono-1,5-lactone + H(+)
  3. 2'-phospho-cyclic ADP-ribose + nicotinate = NAADP(+)

  Catalysed by G6PD, CD38endoplasmic reticulum

• beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucoseReach from here →
  1. D-Glucose-6-phosphate phosphohydrolase
  2. D-glucose + UDP-alpha-D-galactose = lactose + UDP + H(+)
  3. lactose + GDP-beta-L-fucose = beta-D-galactosyl-(1->4)-[alpha-L-fucosyl-(1->3)]-D-glucose + GDP + H(+)

  Catalysed by G6PC1, G6PC3, G6PC2, B4GALT2 and 3 moreendoplasmic reticulum