dUMP

Three steps

• L-alanineReach from here →
  1. dUTP + H2O = dUMP + diphosphate + H(+)
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by DUT, TXN, RRM1, RRM2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• L-asparagineReach from here →
  1. dUTP + H2O = dUMP + diphosphate + H(+)
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by DUT, TXN, RRM1, RRM2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• L-phenylalanineReach from here →
  1. dUTP + H2O = dUMP + diphosphate + H(+)
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. thioredoxin phosphorylation

  Catalysed by DUT, TXN, RRM1, RRM2 and 2 moremitochondrial matrix, cytosolOne of 2 routes

• (2R)-3-phosphoglycerateReach from here →
  1. 2'-deoxyuridine 5'-monophosphate phosphohydrolase
  2. 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
  3. 2-deoxy-alpha-D-ribose 1-phosphate + (2R)-3-phospho-glyceroyl phosphate = 2-deoxy-alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)

  Catalysed by NT5C, NT5M, UPP2, UPP1 and 1 morecytosol

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. 5,10-Methylenetetrahydrofolate:dUMP C-methyltransferase
  2. 5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by TYMS, DHFR, DHFR2, ATICcytosol

• dCDPReach from here →
  1. dUTP + H2O = dUMP + diphosphate + H(+)
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. 2'-deoxycytidine diphosphate:oxidized-thioredoxin 2'-oxidoreductase

  Catalysed by DUT, TXN, RRM1, RRM2 and 2 moremitochondrial matrix, cytosol

• dCTPReach from here →
  1. dUTP + H2O = dUMP + diphosphate + H(+)
  2. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase
  3. 2'-deoxyuridine 5'-triphosphate:oxydized-thioredoxin 2'-oxidoreductase

  Catalysed by DUT, TXN, RRM1, RRM2 and 2 moremitochondrial matrix, cytosol

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. 2'-deoxyuridine 5'-monophosphate phosphohydrolase
  2. 2'-deoxyuridine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + uracil
  3. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

  Catalysed by NT5C, NT5M, UPP2, UPP1 and 1 morecytosol