methylarsonous acid

Three steps

• prostaglandin E2Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin E2 (cytosol to extracellular)

  Catalysed by GSTO1, GSTO2, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• leukotriene D4Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. leukotriene C4 = leukotriene A4 + glutathione
  3. leukotriene C4 + H2O = leukotriene D4 + L-glutamate

  Catalysed by GSTO1, GSTO2, MGST3, GSTM4 and 4 more

• 3-demethylubiquinol-10Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. ubiquinone-10 + hydrogen sulfide + glutathione + H(+) = S-sulfanylglutathione + ubiquinol-10
  3. 3-demethylubiquinol-10 + S-adenosyl-L-methionine = ubiquinol-10 + S-adenosyl-L-homocysteine + H(+)

  Catalysed by GSTO1, GSTO2, SQOR, COQ3

• (R)-noradrenalineReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. L-dehydroascorbate + 2 glutathione = glutathione disulfide + L-ascorbate
  3. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + 2 monodehydro-L-ascorbate radical + H2O

  Catalysed by GSTO1, GSTO2, CLIC1, DBHOne of 3 routes

• CHEBI:730073Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. urate(out) + glutathione(in) = urate(in) + glutathione(out)
  3. Peroxidase

  Catalysed by GSTO1, GSTO2, SLC22A13, MPOinner side of the membrane, outer side of the membrane, nucleusOne of 3 routes

• 20-hydroxy-(5Z,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. Resistance-Nodulation-Cell Division (Rnd) Tcdb:2.A.60.1.5

  Catalysed by GSTO1, GSTO2, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• ursodeoxycholateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GSTO1, GSTO2, PTGES, LANCL1 and 4 moreextracellular space, cytosolOne of 2 routes

• prostaglandin G2Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of prostaglandin G2 (cytosol to extracellular)

  Catalysed by GSTO1, GSTO2, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• an alkyl sulfateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. a hydroperoxide + 2 glutathione = an alcohol + glutathione disulfide + H2O
  3. an alcohol + 3'-phosphoadenylyl sulfate = an alkyl sulfate + adenosine 3',5'-bisphosphate + H(+)

  Catalysed by GSTO1, GSTO2, CP, PRDX6 and 3 more

• thromboxane B2Reach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. 1-chloro-2,4-dinitrobenzene + glutathione = 2,4-dinitrophenyl-S-glutathione + chloride + H(+)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by GSTO1, GSTO2, PTGES, LANCL1 and 3 moreextracellular space, cytosolOne of 2 routes

• (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,11R)-dihydroxy-(6E,8Z,12E,14Z)-eicosatetraenoate + A + H2O

  Catalysed by GSTO1, GSTO2, PTGES, MGST3 and 5 more

• (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15R)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by GSTO1, GSTO2, PTGES, MGST3 and 5 more

• (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoateReach from here →
  1. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
  2. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O
  3. (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + AH2 + O2 = (5S,15S)-dihydroxy-(6E,8Z,11Z,13E)-eicosatetraenoate + A + H2O

  Catalysed by GSTO1, GSTO2, PTGES, MGST3 and 5 more