inosine

Three steps

• 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamideReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. purine nucleoside phosphorylase (nicotinamide)
  3. 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = beta-nicotinamide D-riboside + a quinol

  Catalysed by PNP, NQO2cytosol

• D-sedoheptulose 7-phosphateReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. transketolase (D-xylulose-5-phosphate)

  Catalysed by PNP, PGM2, TKT, TKTL1 and 1 morecytosol

• dCMPReach from here →
  1. transport of adenosine and inosine (cytosol to extracellular)
  2. Adenosine Kinase
  3. UMP/CMP kinase (dCDP)

  No catalyst recordedextracellular space, cytosolOne of 2 routes

• (2R)-3-phospho-glyceroyl phosphateReach from here →
  1. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
  2. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. ATP:3-phospho-D-glycerate 1-phosphotransferase

  Catalysed by PNP, LACC1, PGM2L1, PGK1 and 2 morecytosolOne of 2 routes

• ADP-D-riboseReach from here →
  1. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
  2. alpha-D-ribose 1-phosphate = D-ribose 5-phosphate
  3. D-ribose 5-phosphate + ATP + H(+) = ADP-D-ribose + diphosphate

  Catalysed by PNP, LACC1, PGM2, NUDT5

• 5-phospho-alpha-D-ribose 1-diphosphateReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. ATP:D-ribose-5-phosphate diphosphotransferase

  Catalysed by PNP, PGM2, PRPS2, PRPS1L1 and 1 morecytosolOne of 2 routes

• D-ribulose 5-phosphateReach from here →
  1. inosine:phosphate alpha-D-ribosyltransferase
  2. D-Ribose 1,5-phosphomutase
  3. D-ribose-5-phosphate aldose-ketose-isomerase

  Catalysed by PNP, PGM2, RPIAcytosol, endoplasmic reticulumOne of 2 routes

• (2R)-2-phosphoglycerateReach from here →
  1. inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine
  2. (2R)-3-phospho-glyceroyl phosphate + alpha-D-ribose 1-phosphate = alpha-D-ribose 1,5-bisphosphate + (2R)-3-phosphoglycerate + H(+)
  3. D-phosphoglycerate 2,3-phosphomutase

  Catalysed by PNP, LACC1, PGM2L1, BPGM and 3 morecytosolOne of 2 routes

• 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →
  1. ATP:inosine 5'-phosphotransferase
  2. IMP 1,2-hydrolase (decyclizing)
  3. phosphoribosylaminoimidazolecarboxamide formyltransferase (10-formyl-THF)

  Catalysed by ATICmitochondrial matrix, cytosol

• 2-deoxy-D-ribose 5-phosphateReach from here →
  1. dIMP + inosine = 2'-deoxyinosine + IMP
  2. 2'-deoxyinosine + phosphate = 2-deoxy-alpha-D-ribose 1-phosphate + hypoxanthine
  3. 2-deoxy-alpha-D-ribose 1-phosphate = 2-deoxy-D-ribose 5-phosphate

  Catalysed by NT5C2, PNP, PGM2