sulfate

Three steps

• 3-methylmalateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)
  3. propanoyl-CoA + glyoxylate + H2O = 3-methylmalate + CoA + H(+)

  Catalysed by SLC25A10, CLYBLmitochondrial matrix, cytosol

• tricosanoyl-CoAReach from here →
  1. L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)
  2. acetyl-CoA:L-aspartate N-acetyltransferase
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by SLC25A14, SLC25A30, NAT8L, SLC27A2 and 7 moreinner side of the membrane, outer side of the membrane, mitochondrial matrix, cytosolOne of 4 routes

• (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (5S)-hydroperoxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + 2 glutathione = (5S)-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, PTGES and 5 moreinner side of the membrane, outer side of the membrane

• (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (12S)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + 2 glutathione = (12S)-hydroxy-(5Z,8Z,10E,14Z)-eicosatetraenoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX1 and 1 moreinner side of the membrane, outer side of the membrane

• thromboxane B2Reach from here →
  1. dehydroepiandrosterone 3-sulfate + H2O = 3beta-hydroxyandrost-5-en-17-one + sulfate + H(+)
  2. transport of dehydroepiandrosterone sulfate (cytosol to extracellular)
  3. transport of S-glutathionyl-2-4-dinitrobenzene (cytosol to extracellular)

  Catalysed by STS, SLCO1B1extracellular space, cytosolOne of 2 routes

• an S-substituted glutathioneReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC25A14, SLC25A30, TSTD1, GSTT4 and 22 moreinner side of the membrane, outer side of the membraneOne of 2 routes

• (13S)-hydroxy-(9Z,11E)-octadecadienoateReach from here →
  1. sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)
  2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
  3. (13S)-hydroperoxy-(9Z,11E)-octadecadienoate + 2 glutathione = (13S)-hydroxy-(9Z,11E)-octadecadienoate + glutathione disulfide + H2O

  Catalysed by SLC25A14, SLC25A30, TSTD1, GPX1 and 3 moreinner side of the membrane, outer side of the membrane

• taurochenodeoxycholateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  3. 3alpha,7alpha-dihydroxy-5beta-cholanoyl-CoA:taurine N-choloyltransferase

  Catalysed by SLC26A6, SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 6 routes

• 2-(1-hydroxyethyl)thiamine diphosphateReach from here →
  1. transport of malate and sulfate (cytosol to mitochondria)
  2. (S)-malate:NAD+ oxidoreductase (decarboxylating)
  3. pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)

  Catalysed by SLC25A10, ME2, ME3, PDHA1 and 2 moremitochondrial matrix, cytosol