hexadecan-1-ol

Three steps

• (R)-3-hydroxy-(11Z)-octadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Production of 3-Hydroxyoctadecenoylcarnitinec

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosol

• (13Z)-eicosenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase ((13Z)-eicosenoic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 5 routes

• 4,8-dimethylnonanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by GNPAT, CRAT, CROTperoxisome, cytosolOne of 3 routes

• tetradecanedioyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C16Dc->C14Dc), Peroxisomal

  Catalysed by GNPAT, ACAA1, HSD17B4, EHHADH and 1 moreperoxisome, cytosol

• hexadecanedioyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Production of Hexadecanedioylcarnitine

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, cytosolOne of 2 routes

• O-dodecanoyl-R-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. carnitine O-palmitoyltransferase (dodecanoylcarnitine)

  Catalysed by GNPAT, CPT1A, CPT1C, CPT1Bperoxisome, endoplasmic reticulum, cytosolOne of 7 routes

• 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerolReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. 1-octadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol + H2O = 2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-glycerol + octadecanoate + H(+)

  Catalysed by GNPAT, ABHD11peroxisome, cytosol

• (11Z,14Z)-eicosadienoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (17Z)-hexacosenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z,19Z)-docosapentaenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• (7Z,10Z,13Z,16Z)-docosatetraenoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• pristanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. fatty-acid-CoA ligase

  Catalysed by GNPAT, SLC27A2peroxisome, cytosolOne of 2 routes

• 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 1-O-(1Z-alkenyl)-sn-glycero-3-phosphocholine + hexadecanoyl-CoA = 1-O-(1Z)-alkenyl-2-hexadecanoyl-sn-glycero-3-phosphocholine + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. a 2-acyl-sn-glycero-3-phosphoethanolamine + hexadecanoyl-CoA = 1-hexadecanoyl-2-acyl-sn-glycero-3-phosphoethanolamine + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• undecanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. medium-chain acyl-CoA ligase (undecylic acid)

  Catalysed by GNPAT, ACSM4, ACSM1, ACSM2A and 3 moreperoxisome, cytosolOne of 3 routes

• (5Z,8Z,11Z)-eicosatrienoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• tricosanoateReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. (10Z)-heptadecenoic acid formation
  3. (10Z)-heptadecenoic acid formation

  Catalysed by GNPATperoxisome, cytosol, extracellular spaceOne of 12 routes

• N-hexadecanoylhexadecasphinganineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. hexadecasphinganine + hexadecanoyl-CoA = N-hexadecanoylhexadecasphinganine + CoA + H(+)

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 10 more

• 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. hexadecanoate + ATP + CoA = hexadecanoyl-CoA + AMP + diphosphate
  3. 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-glycerol + hexadecanoyl-CoA = 1'-[1,2-di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho]-3'-[1-(9Z,12Z-octadecadienoyl)-2-hexadecanoyl-sn-glycero-3-phospho]-glycerol + CoA

  Catalysed by AGPS, SLC27A2, ACSL4, ACSL3 and 9 more

• (5Z)-tetradecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (physeteric acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 8 routes

• O-4,8-dimethylnonanoyl-(R)-carnitineReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Utilized Transport
  3. Carnitine Dimethyl Nonanoyl Transferase, Revsible, Peroxisomal

  Catalysed by GNPAT, CRAT, CROTperoxisome, endoplasmic reticulum, cytosolOne of 5 routes

• beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enineReach from here →
  1. 1-hexadecanoylglycerone 3-phosphate + hexadecan-1-ol = 1-O-hexadecylglycerone 3-phosphate + hexadecanoate + H(+)
  2. N-hexadecanoylsphing-4-enine + H2O = sphing-4-enine + hexadecanoate
  3. beta-D-glucosyl-(1<->1')-N-hexadecanoylsphing-4-enine + cholesterol = cholesteryl 3-beta-D-glucoside + N-hexadecanoylsphing-4-enine

  Catalysed by AGPS, NAAA, ASAH1, ACER2 and 2 more

• (3E)-decenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. Fatty Acid Beta Oxidation (C12:1->C10:1), Mitochondrial

  Catalysed by GNPAT, ACADM, ECHS1, ACAA2 and 1 moreperoxisome, cytosol, mitochondrial matrix

• (2R,6)-dimethylheptanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. acetyl-CoA C-acyltransferase (3-oxo-4(R),8-dimethyl-nonanoyl-CoA)

  Catalysed by GNPAT, HADHA, ACAA2, HADHBperoxisome, cytosol, mitochondrial matrix

• (7Z)-hexadecenoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Palmitate:CoA ligase (AMP-forming)
  3. stearoyl-CoA 9-desaturase (palmitoyl-CoA)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 7 moreperoxisome, cytosolOne of 9 routes

• tricosanoyl-CoAReach from here →
  1. glyceronephosphate O-acyltransferase (1-palmitoyl-dihydroxyacetone-phosphate)
  2. Fas180
  3. long-chain-fatty-acid-CoA ligase (tricosanoic acid)

  Catalysed by GNPAT, SLC27A2, ACSL4, ACSL3 and 5 moreperoxisome, cytosolOne of 4 routes