CHEBI:15467

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

625 compounds within 3 steps: 4 in 1, 124 in 2, 497 in 3

Three steps

1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
(11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. (9Z,12Z)-octadecadienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z)-3-oxoicosa-11,14-dienoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 9 morecytosol
(11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (linolenate)
3. (9Z,12Z,15Z)-octadecatrienoyl-CoA + malonyl-CoA + H(+) = (11Z,14Z,17Z)-3-oxoeicosatrienoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 9 morecytosol
3-oxo-(13Z)-docosenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (cis-gondoic acid)
3. (11Z)-eicosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(13Z)-docosenoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
3-oxo-(15Z)-tetracosenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (cis-erucic acid)
3. (13Z)-docosenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(15Z)-tetracosenoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
2-hydroxyoctadecanoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. octadecanoyl-CoA + 2-oxoglutarate + O2 = 2-hydroxyoctadecanoyl-CoA + succinate + CO2
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
N-(15Z-tetracosenoyl)-sphinganineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (nervonic acid)
3. (15Z)-tetracosenoyl-CoA + sphinganine = N-(15Z-tetracosenoyl)-sphinganine + CoA + H(+)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
N-tetracosanoyl-heptadecasphing-4-enineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. heptadecasphing-4-enine + tetracosanoyl-CoA = N-tetracosanoyl-heptadecasphing-4-enine + CoA + H(+)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(2E)-hexacosenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (cerotic acid)
3. acyl-CoA oxidase (hexacosanoyl-CoA)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 2 routes
3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z,12Z,15Z,18Z,21Z)-THA)
3. (6Z,9Z,12Z,15Z,18Z,21Z)-tetracosahexaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(8Z,11Z,14Z,17Z,20Z,23Z)-hexacosahexaenoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(2S)-2-aminobutanoateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. glycine N-acyltransferase (N-arachidonoylglycine)
3. (2S)-2-aminobutanoate + glyoxylate = 2-oxobutanoate + glycine
Catalysed by HMGCR, GLYAT, GLYATL2, GLYATL1 and 1 morecytosol, mitochondrial matrixOne of 2 routes
N-(15Z-tetracosenoyl)-sphing-4-enineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. acyl-CoA:sphingosine N-acyltransferase
3. N-(15Z-tetracosenoyl)-sphing-4-enine + H2O = (15Z)-tetracosenoate + sphing-4-enine
Catalysed by HMGCR, ASAH1, ACER2, ACER1 and 1 morecytosol, Golgi apparatus
N-(tetracosenoyl)-sphing-4-enineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. acyl-CoA:sphingosine N-acyltransferase
3. tetracosenoyl-CoA + sphing-4-enine = N-(tetracosenoyl)-sphing-4-enine + CoA + H(+)
Catalysed by HMGCR, ASAH1, ACER2, ACER1 and 2 morecytosol, Golgi apparatus
1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. glycerol-3-phosphate 1-O-acyltransferase (linoleoyl-CoA)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 9 morecytosolOne of 2 routes
1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 10 morecytosol
1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (margaric acid)
3. heptadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-heptadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 10 morecytosol
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 11 morecytosol
1-octadecanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. glycerol-3-phosphate 1-O-acyltransferase (sn-glycerol-3-phosphate)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 8 morecytosolOne of 2 routes
1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (myristic acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + tetradecanoyl-CoA = 1-(9Z)-octadecenoyl-2-tetradecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 10 morecytosol
3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((9Z,12Z,15Z,18Z,21Z)-TPA)
3. (9Z,12Z,15Z,18Z,21Z)-tetracosapentaenoyl-CoA + malonyl-CoA + H(+) = 3-oxo-(11Z,14Z,17Z,20Z,23Z)-hexacosapentaenoyl-CoA + CO2 + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
(2E)-eicosenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. acyl-CoA oxidase (eicosanoyl-CoA)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 4 routes
(2E)-docosenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (behenic acid)
3. acyl-CoA oxidase (docosanoyl-CoA)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 4 routes
(2E)-tetracosenoyl-CoAReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lignocerate)
3. acyl-CoA oxidase (tetracosanoyl-CoA)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol, peroxisomeOne of 3 routes
1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. (9Z)-hexadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z,12Z-octadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (palmitolate)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + (9Z)-hexadecenoyl-CoA = 1-(9Z-octadecenoyl)-2-(9Z-hexadecenoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phospho-L-serine + octadecanoyl-CoA = 1-(9Z-octadecenoyl)-2-octadecanoyl-sn-glycero-3-phospho-L-serine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (eicosanoate)
3. eicosanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-eicosanoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. Arachidonate:CoA ligase (AMP-forming)
3. glycerol-3-phosphate 1-O-acyltransferase (arachidonyl-CoA)
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 9 morecytosol
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (DHA)
3. (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-(9Z)-octadecenoyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. dodecanoyl-CoA + 1-hexadecanoyl-sn-glycero-3-phosphocholine = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phosphocholine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 7 morecytosol
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + octadecanoyl-CoA = 1-octadecanoyl-2-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. a 1-acyl-sn-glycero-3-phospho-L-serine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phospho-L-serine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. a 1-acyl-sn-glycero-3-phosphoethanolamine + (9Z,12Z)-octadecadienoyl-CoA = 1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate + dodecanoyl-CoA = 1-(9Z)-octadecenoyl-2-dodecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (nonadecylic acid)
3. nonadecanoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-nonadecanoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 8 morecytosol
1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphateReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. Transport of 11-Octadecenoyl Carnitine into the Mitochondrial Matrix
3. (11Z)-octadecenoyl-CoA + 1-(9Z-octadecenoyl)-sn-glycero-3-phosphate = 1-(9Z)-octadecenoyl-2-(11Z)-octadecenoyl-sn-glycero-3-phosphate + CoA
Catalysed by HMGCR, CPT1A, CPT1C, CPT1B and 2 morecytosol
1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol)Reach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1-hexadecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + dodecanoyl-CoA = 1-hexadecanoyl-2-dodecanoyl-sn-glycero-3-phospho-(1D-myo-inositol) + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1-acyl-2-dodecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (lauric acid)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + dodecanoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-dodecanoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerolReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl,2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase (stearate)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + octadecanoyl-CoA = 1'-[1-acyl-2-octadecanoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 5 morecytosol
1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerolReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. long-chain-fatty-acid-CoA ligase ((6Z,9Z)-octadecadienoic acid)
3. 1',3'-bis-[1-acyl-sn-glycero-3-phospho]-glycerol + (9Z,12Z)-octadecadienoyl-CoA = 1'-[1-acyl-2-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phospho],3'-[1-acyl,2-hydroxy-sn-glycero-3-phospho]-glycerol + CoA
Catalysed by HMGCR, SLC27A2, ACSL4, ACSL3 and 6 morecytosol
1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamineReach from here →
1. (R)-Mevalonate:NADP+ oxidoreductase (CoA acylating)
2. Octanoyl-CoA:L-carnitine O-octanoyltransferase
3. octanoyl-CoA + a 1-acyl-sn-glycero-3-phosphoethanolamine = 1-acyl-2-octanoyl-sn-glycero-3-phosphoethanolamine + CoA
Catalysed by HMGCR, CROT, LPCAT4cytosol, mitochondrial matrix