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Proteins/UNIPROT:O96006
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins..
(Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection..
Function from UniProtKB (O96006), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
38 statements
38 statements · 3 reference databases · Subject: ZBED1 · Sources: gene ontology, Hetionet, Reactome
9 names
Resolves to: ZBED1