Compound

a long-chain fatty acyl-CoA

A fatty acyl-CoA(4−) arising from deprotonation of the phosphate and diphosphate OH groups of any long-chain fatty acyl-CoA; major species at pH 7.3.

Definition from ChEBI (CHEBI:83139), read 2026-09-23. CC BY 4.0.

CHEBI:83139ChEBI

Open in the graph

Structure

2D depiction

Class: Organic compound, anion
Formula: C22H31N7O17P3SR
Mass: 790.507 g/mol
Charge: -4
SMILES: *C(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(=O)([O-])OP(=O)([O-])OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1OP(=O)([O-])[O-]
Look it up: ChEBI

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Statements

2 statements

2 statements · 1 reference database · Subject: a long-chain fatty acyl-CoA · Sources: Rhea

Order

a long-chain fatty acyl-CoA is a substrate of ACAA1ProteinRhea RHEA:78899Inferred only
a long-chain fatty acyl-CoA is a substrate of HADHBProteinRhea RHEA:78899Inferred only

Reactions

11 reactions

a long-chain fatty acid+ATP(4-)+coenzyme A(4-)a long-chain fatty acyl-CoA+AMP+diphosphate(3-)
Catalysed by SLC27A2 or ACSL4 or ACSL3 or ACSL1 or ACSBG2 or SLC27A3 or SLC27A4 or SLC27A1 or ACSBG1 or ACSL6 or ACSL5 or SLC27A6 and 1 more alternative
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:15421CC BY 4.0Reference data
CHEBI:17176+NADP(3-)+coenzyme A(4-)a long-chain fatty acyl-CoA+NADPH(4-)+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:15437CC BY 4.0Reference data
nmalonyl-CoA+acetyl-CoA+2nNADPH+2nH(+)a long-chain fatty acyl-CoA+ncarbon dioxide+2nNADP(+)+ncoenzyme A(4-)+water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:22896CC BY 4.0Reference data
a long-chain fatty acyl-CoAa long-chain fatty acyl-CoA
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:39707CC BY 4.0Reference data
holo-[mycolipanoate synthase]+a long-chain fatty acyl-CoA+3(S)-methylmalonyl-CoA+6NADPH(4-)+9hydronlong-chain mycolipanoyl-[mycolipanoate synthase]+3carbon dioxide+6NADP(3-)+4coenzyme A(4-)+3water
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:50344CC BY 4.0Reference data
a long-chain fatty acyl-CoA+2NADPH(4-)+2hydronCHEBI:77396+2NADP(3-)+coenzyme A(4-)
Catalysed by FAR1 or FAR2
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:52716CC BY 4.0Reference data
a long-chain fatty acyl-CoA+alpha,alpha-trehaloseCHEBI:142477+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:58044CC BY 4.0Reference data
a sterol+a long-chain fatty acyl-CoACHEBI:232093+coenzyme A(4-)
Catalysed by SOAT2 or SOAT1
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:59816CC BY 4.0Reference data
a long-chain fatty acyl-CoA+watera long-chain fatty acid+coenzyme A(4-)+hydron
Catalysed by ACOT7 or ABCD3
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:67680CC BY 4.0Reference data
a long-chain fatty acyl-CoA+acetyl-CoAa long-chain 3-oxo-fatty acyl-CoA+coenzyme A(4-)
Catalysed by ACAA1 or HADHB
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:78899CC BY 4.0Reference data
a long-chain fatty acyl-CoA+2NADH(2-)+2hydronCHEBI:77396+2NAD(1-)+coenzyme A(4-)
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:84767CC BY 4.0Reference data

Other names

1 name

Resolves to: a long-chain fatty acyl-CoA

Also called: Long-chain fatty acyl-CoA