Proteins/UNIPROT:O94761

RECQL4

ProteinUNIPROT:O94761

An ATP-dependent DNA helicase which unwinds dsDNA with a 3'-overhang in a 3'-5' direction. Does not unwind more than 18 bp of dsDNA. May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA. The core helicase domain binds ssDNA..

Function from UniProtKB (O94761), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

Baller-Gerold syndrome has a germline basis in RECQL4DiseaseGenCC HGNC:9949|MONDO:0009039Inferred only
osteosarcoma has a germline basis in RECQL4DiseaseGenCC HGNC:9949|MONDO:0009807Inferred only
rapadilino syndrome has a germline basis in RECQL4DiseaseGenCC HGNC:9949|MONDO:0009955Inferred only
Rothmund-Thomson syndrome has a germline basis in RECQL4DiseaseGenCC HGNC:9949|MONDO:0010002Inferred only
Rothmund-Thomson syndrome type 2 has a germline basis in RECQL4DiseaseGenCC HGNC:9949|MONDO:0016369Inferred only

Statements

31 statements

31 statements · 3 reference databases · Subject: RECQL4 · Sources: Hetionet, UniProt, WikiPathways

Order

RECQL4 covaries with AMER2ProteinHetionet hetionet:covaries:219287-9401Inferred only
RECQL4 covaries with C21orf58ProteinHetionet hetionet:covaries:54058-9401Inferred only
RECQL4 covaries with FBXO8ProteinHetionet hetionet:covaries:26269-9401Inferred only
RECQL4 covaries with KCTD8ProteinHetionet hetionet:covaries:386617-9401Inferred only
MAMDC4 covaries with RECQL4ProteinHetionet hetionet:covaries:158056-9401Inferred only
RECQL4 covaries with POU5F2ProteinHetionet hetionet:covaries:134187-9401Inferred only
RECQL4 covaries with SLC19A1ProteinHetionet hetionet:covaries:6573-9401Inferred only
STARD8 covaries with RECQL4ProteinHetionet hetionet:covaries:9401-9754Inferred only
TONSL covaries with RECQL4ProteinHetionet hetionet:covaries:4796-9401Inferred only
RECQL4 interacts with ACDProteinHetionet hetionet:interacts:65057-9401Inferred only
EP300 interacts with RECQL4ProteinHetionet hetionet:interacts:2033-9401Inferred only
RECQL4 interacts with PRSS23ProteinHetionet hetionet:interacts:11098-9401Inferred only

Show the remaining 19

RAD51 interacts with RECQL4ProteinHetionet hetionet:interacts:5888-9401Inferred only
TERF1 interacts with RECQL4ProteinHetionet hetionet:interacts:7013-9401Inferred only
RECQL4 interacts with TERF2IPProteinHetionet hetionet:interacts:54386-9401Inferred only
UBC interacts with RECQL4ProteinHetionet hetionet:interacts:7316-9401Inferred only
RECQL4 participates in DNA IR damage and cellular response via ATRPathwayWikiPathways WP4016Inferred only
RECQL4 participates in Primary ovarian insufficiencyPathwayWikiPathways WP5461Inferred only
ATP2C1 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:27032-9401Inferred only
CDK6 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:1021-9401Inferred only
DYRK1A increases the expression of RECQL4ProteinHetionet hetionet:regulates:1859-9401Inferred only
FGFR1 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:2260-9401Inferred only
ORC1 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:4998-9401Inferred only
PHGDH decreases the expression of RECQL4ProteinHetionet hetionet:regulates:26227-9401Inferred only
PPP4R1 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:9989-9401Inferred only
PRP4K decreases the expression of RECQL4ProteinHetionet hetionet:regulates:8899-9401Inferred only
RAD51 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:5888-9401Inferred only
SLC25A4 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:291-9401Inferred only
SPR decreases the expression of RECQL4ProteinHetionet hetionet:regulates:6697-9401Inferred only
VPS28 decreases the expression of RECQL4ProteinHetionet hetionet:regulates:51160-9401Inferred only
RECQL4 requires the cofactor Zn(2+)CompoundUniProt O94761Inferred only

Reactions

1 reaction

ATP(4-)+waterADP(3-)+hydrogenphosphate+hydron
Catalysed by HFM1 or SMCHD1 or FIGNL2 or DDX39A or DDX3X or CHD1 or CHD2 or TOR1A or TOR1B or DDX3Y or DHX15 or GET3 and 193 more alternatives

Other names

5 names

Resolves to: RECQL4

Also called: DNA 3'-5' helicase RecQ4DNA helicase, RecQ-like type 4RecQ protein-like 4RECQ4RTS

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