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Proteins/UNIPROT:C9JXX5
Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome. Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP..
Function from UniProtKB (C9JXX5), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
6 statements
6 statements · 2 reference databases · Subject: FREY1 · Sources: Hetionet, WikiPathways
3 names
Resolves to: FREY1