Proteins/UNIPROT:Q12805

EFEMP1

ProteinUNIPROT:Q12805

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth..

Function from UniProtKB (Q12805), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

5 rows

autosomal recessive cutis laxa type 1 has a germline basis in EFEMP1DiseaseGenCC HGNC:3218|MONDO:0019572Inferred only
cutis laxa, autosomal recessive, type 1d has a germline basis in EFEMP1DiseaseGenCC HGNC:3218|MONDO:0958335Inferred only
Doyne honeycomb retinal dystrophy has a germline basis in EFEMP1DiseaseGenCC HGNC:3218|MONDO:0007471Inferred only
juvenile open angle glaucoma has a germline basis in EFEMP1DiseaseGenCC HGNC:3218|MONDO:0020367Inferred only
open-angle glaucoma has a germline basis in EFEMP1DiseaseGenCC HGNC:3218|MONDO:0005338Inferred only

Statements

22 statements

22 statements · 3 reference databases · Subject: EFEMP1 · Sources: gene ontology, Hetionet, Reactome

Order

ARAF interacts with EFEMP1ProteinHetionet hetionet:interacts:2202-369Inferred only
ATN1 interacts with EFEMP1ProteinHetionet hetionet:interacts:1822-2202Inferred only
EFEMP1 interacts with ATXN7ProteinHetionet hetionet:interacts:2202-6314Inferred only
CACNA1A interacts with EFEMP1ProteinHetionet hetionet:interacts:2202-773Inferred only
ECM1 interacts with EFEMP1ProteinHetionet hetionet:interacts:1893-2202Inferred only
EFEMP1 interacts with GFI1BProteinHetionet hetionet:interacts:2202-8328Inferred only
EFEMP1 interacts with KHDRBS1ProteinHetionet hetionet:interacts:10657-2202Inferred only
EFEMP1 interacts with NOS3ProteinHetionet hetionet:interacts:2202-4846Inferred only
EFEMP1 interacts with PDIA3ProteinHetionet hetionet:interacts:2202-2923Inferred only
EFEMP1 interacts with RAF1ProteinHetionet hetionet:interacts:2202-5894Inferred only
RERE interacts with EFEMP1ProteinHetionet hetionet:interacts:2202-473Inferred only
EFEMP1 interacts with SGTAProteinHetionet hetionet:interacts:2202-6449Inferred only

Show the remaining 10

EFEMP1 interacts with SOCS6ProteinHetionet hetionet:interacts:2202-9306Inferred only
EFEMP1 interacts with TNIP1ProteinHetionet hetionet:interacts:10318-2202Inferred only
EFEMP1 interacts with UBCProteinHetionet hetionet:interacts:2202-7316Inferred only
EFEMP1 participates in Elastic fibre formationPathwayReactome R-HSA-1566948Inferred only
EFEMP1 participates in Extracellular matrix organizationPathwayReactome R-HSA-1474244Inferred only
EFEMP1 participates in Molecules associated with elastic fibresPathwayReactome R-HSA-2129379Inferred only
EFEMP1 regulates negative regulation of chondrocyte differentiationBiological processgene ontology Q12805|GO:0032331Inferred only
EFEMP1 regulates regulation of DNA-templated transcriptionBiological processgene ontology Q12805|GO:0006355Inferred only
ELP1 decreases the expression of EFEMP1ProteinHetionet hetionet:regulates:8518-2202Inferred only
FOS decreases the expression of EFEMP1ProteinHetionet hetionet:regulates:2353-2202Inferred only

Other names

6 names

Resolves to: EFEMP1

Also called: Extracellular protein S1-5FBLN3FBNLFIBL-3Fibrillin-like proteinFibulin-3

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