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Proteins/UNIPROT:P55017
Electroneutral sodium and chloride ion cotransporter, which acts as a key mediator of sodium and chloride reabsorption in kidney distal convoluted tubules. Also acts as a receptor for the pro-inflammatory cytokine IL18, thereby contributing to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2 (By similarity). May act either independently of IL18R1, or in a complex with IL18R1 (By similarity)..
Function from UniProtKB (P55017), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
18 statements
18 statements · 6 reference databases · Subject: SLC12A3 · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
chlorine(.)+sodium(1+)chlorine(.)+sodium(1+)
Transported by SLC12A3
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06524CC BY 4.0Reference data
chloride+sodium(1+)chloride+sodium(1+)
Transported by SLC12A3
Reaction pageDirection not assertedBalanced
Rhea RHEA:73887CC BY 4.0
5 names
Resolves to: SLC12A3