Proteins/UNIPROT:Q8NE63

HIPK4

ProteinUNIPROT:Q8NE63

Protein kinase that phosphorylates human TP53 at Ser-9, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential)..

Function from UniProtKB (Q8NE63), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

16 statements

16 statements · 1 reference database · Subject: HIPK4 · Sources: Hetionet

Order

HIPK4 covaries with AKAP3ProteinHetionet hetionet:covaries:10566-147746Inferred only
GRIN1 covaries with HIPK4ProteinHetionet hetionet:covaries:147746-2902Inferred only
KCTD12 covaries with HIPK4ProteinHetionet hetionet:covaries:115207-147746Inferred only
HIPK4 covaries with PDE8AProteinHetionet hetionet:covaries:147746-5151Inferred only
STMN4 covaries with HIPK4ProteinHetionet hetionet:covaries:147746-81551Inferred only
TECTA covaries with HIPK4ProteinHetionet hetionet:covaries:147746-7007Inferred only
TMEM121B covaries with HIPK4ProteinHetionet hetionet:covaries:147746-27439Inferred only
XKR6 covaries with HIPK4ProteinHetionet hetionet:covaries:147746-286046Inferred only
HSP90AA1 interacts with HIPK4ProteinHetionet hetionet:interacts:147746-3320Inferred only
HSP90AB1 interacts with HIPK4ProteinHetionet hetionet:interacts:147746-3326Inferred only
HIPK4 decreases the expression of DENND2DProteinHetionet hetionet:regulates:147746-79961Inferred only
HIPK4 decreases the expression of H2BC12ProteinHetionet hetionet:regulates:147746-85236Inferred only

Show the remaining 4

HIPK4 increases the expression of IDEProteinHetionet hetionet:regulates:147746-3416Inferred only
HIPK4 decreases the expression of ITGAEProteinHetionet hetionet:regulates:147746-3682Inferred only
HIPK4 increases the expression of PRCPProteinHetionet hetionet:regulates:147746-5547Inferred only
HIPK4 increases the expression of SNX7ProteinHetionet hetionet:regulates:147746-51375Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

1 name

Resolves to: HIPK4

Also called: Homeodomain-interacting protein kinase 4

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