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Proteins/UNIPROT:Q9H3P2

NELFA

Protein·UNIPROT:Q9H3P2

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Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex..

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(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II..

Function from UniProtKB (Q9H3P2), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

45 statements

45 statements · 4 reference databases · Subject: NELFA · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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APP interacts with NELFAProteinHetionet hetionet:interacts:351-7469Inferred only
NELFA interacts with NELFBProteinHetionet hetionet:interacts:25920-7469Inferred only
NELFA interacts with NELFCDProteinHetionet hetionet:interacts:51497-7469Inferred only
NELFA interacts with NELFEProteinHetionet hetionet:interacts:7469-7936Inferred only
POLR2A interacts with NELFAProteinHetionet hetionet:interacts:5430-7469Inferred only
SUMO2 interacts with NELFAProteinHetionet hetionet:interacts:6613-7469Inferred only
UBC interacts with NELFAProteinHetionet hetionet:interacts:7316-7469Inferred only
NELFA participates in 4p16 3 copy number variationPathwayWikiPathways WP5365Inferred only
NELFA participates in Abortive elongation of HIV-1 transcript in the absence of TatPathwayReactome R-HSA-167242Inferred only
NELFA participates in Adaptive Immune SystemPathwayReactome R-HSA-1280218Inferred only
NELFA participates in Affinity selection of immunoglobulinsPathwayReactome R-HSA-9938027Inferred only
NELFA participates in DiseasePathwayReactome R-HSA-1643685Inferred only

Show the remaining 33

NELFA participates in Formation of HIV elongation complex in the absence of HIV TatPathwayReactome R-HSA-167152Inferred only
NELFA participates in Formation of HIV-1 elongation complex containing HIV-1 TatPathwayReactome R-HSA-167200Inferred only
NELFA participates in Formation of RNA Pol II elongation complexPathwayReactome R-HSA-112382Inferred only
NELFA participates in Formation of the Early Elongation ComplexPathwayReactome R-HSA-113418Inferred only
NELFA participates in Formation of the HIV-1 Early Elongation ComplexPathwayReactome R-HSA-167158Inferred only
NELFA participates in Gene expression (Transcription)PathwayReactome R-HSA-74160Inferred only
NELFA participates in Generic Transcription PathwayPathwayReactome R-HSA-212436Inferred only
NELFA participates in HIV elongation arrest and recoveryPathwayReactome R-HSA-167287Inferred only
NELFA participates in HIV InfectionPathwayReactome R-HSA-162906Inferred only
NELFA participates in HIV Life CyclePathwayReactome R-HSA-162587Inferred only
NELFA participates in HIV Transcription ElongationPathwayReactome R-HSA-167169Inferred only
NELFA participates in Immune SystemPathwayReactome R-HSA-168256Inferred only
NELFA participates in Immunoglobulin maturationPathwayReactome R-HSA-9938026Inferred only
NELFA participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
NELFA participates in Initiation of transcription and translation elongation at the HIV 1 LTRPathwayWikiPathways WP3414Inferred only
NELFA participates in Late Phase of HIV Life CyclePathwayReactome R-HSA-162599Inferred only
NELFA participates in Pausing and recovery of HIV elongationPathwayReactome R-HSA-167290Inferred only
NELFA participates in Pausing and recovery of Tat-mediated HIV elongationPathwayReactome R-HSA-167238Inferred only
NELFA participates in RNA Polymerase II Pre-transcription EventsPathwayReactome R-HSA-674695Inferred only
NELFA participates in RNA Polymerase II TranscriptionPathwayReactome R-HSA-73857Inferred only
NELFA participates in RNA Polymerase II Transcription ElongationPathwayReactome R-HSA-75955Inferred only
NELFA participates in RNA polymerase II transcription the preinitiation complexPathwayWikiPathways WP5563Inferred only
NELFA participates in Somatic hypermutation of immunoglobulin genesPathwayReactome R-HSA-9938024Inferred only
NELFA participates in Tat-mediated elongation of the HIV-1 transcriptPathwayReactome R-HSA-167246Inferred only
NELFA participates in Tat-mediated HIV elongation arrest and recoveryPathwayReactome R-HSA-167243Inferred only
NELFA participates in TP53 Regulates Transcription of DNA Repair GenesPathwayReactome R-HSA-6796648Inferred only
NELFA participates in Transcription of the HIV genomePathwayReactome R-HSA-167172Inferred only
NELFA participates in Transcriptional Regulation by TP53PathwayReactome R-HSA-3700989Inferred only
NELFA participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only
NELFA regulates negative regulation of transcription elongation by RNA polymerase IIBiological processgene ontology Q9H3P2|GO:0034244Inferred only
NELFA regulates positive regulation of transcription by RNA polymerase IIBiological processgene ontology Q9H3P2|GO:0045944Inferred only
ESPL1 increases the expression of NELFAProteinHetionet hetionet:regulates:9700-7469Inferred only
LRPAP1 decreases the expression of NELFAProteinHetionet hetionet:regulates:4043-7469Inferred only

Other names

3 names

Resolves to: NELFA

Also called: NELF-AWHSC2Wolf-Hirschhorn syndrome candidate 2 protein

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