Proteins/UNIPROT:P61328

FGF12

ProteinUNIPROT:P61328

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation..

Function from UniProtKB (P61328), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

3 rows

developmental and epileptic encephalopathy, 47 has a germline basis in FGF12DiseaseGenCC HGNC:3668|MONDO:0014949Inferred only
genetic developmental and epileptic encephalopathy has a germline basis in FGF12DiseaseGenCC HGNC:3668|MONDO:0100062Inferred only
undetermined early-onset epileptic encephalopathy has a germline basis in FGF12DiseaseGenCC HGNC:3668|MONDO:0018614Inferred only

Statements

37 statements

37 statements · 4 reference databases · Subject: FGF12 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

ADGRL1 covaries with FGF12ProteinHetionet hetionet:covaries:2257-22859Inferred only
FGF12 covaries with CDR2LProteinHetionet hetionet:covaries:2257-30850Inferred only
H2BC4; H2BC6; H2BC7; H2BC8; H2BC10 covaries with FGF12ProteinHetionet hetionet:covaries:2257-8339Inferred only
H3C1; H3C2; H3C3; H3C4; H3C6; H3C7; H3C8; H3C10; H3C11; H3C12 covaries with FGF12ProteinHetionet hetionet:covaries:2257-8357Inferred only
HNRNPA0 covaries with FGF12ProteinHetionet hetionet:covaries:10949-2257Inferred only
FGF12 covaries with JOSD2ProteinHetionet hetionet:covaries:126119-2257Inferred only
FGF12 covaries with KRASProteinHetionet hetionet:covaries:2257-3845Inferred only
FGF12 covaries with LHFPL4ProteinHetionet hetionet:covaries:2257-375323Inferred only
NELFE covaries with FGF12ProteinHetionet hetionet:covaries:2257-7936Inferred only
NRF1 covaries with FGF12ProteinHetionet hetionet:covaries:2257-4899Inferred only
ORAI1 covaries with FGF12ProteinHetionet hetionet:covaries:2257-84876Inferred only
SAMD5 covaries with FGF12ProteinHetionet hetionet:covaries:2257-389432Inferred only

Show the remaining 25

SNX12 covaries with FGF12ProteinHetionet hetionet:covaries:2257-29934Inferred only
SPIN1 covaries with FGF12ProteinHetionet hetionet:covaries:10927-2257Inferred only
FGF12 covaries with TAFA5ProteinHetionet hetionet:covaries:2257-25817Inferred only
FGF12 covaries with TRAF7ProteinHetionet hetionet:covaries:2257-84231Inferred only
FGF12 covaries with WNT7BProteinHetionet hetionet:covaries:2257-7477Inferred only
APP interacts with FGF12ProteinHetionet hetionet:interacts:2257-351Inferred only
FGF12 interacts with MAPK13ProteinHetionet hetionet:interacts:2257-5603Inferred only
FGF12 interacts with NEDD4ProteinHetionet hetionet:interacts:2257-4734Inferred only
FGF12 interacts with NEDD4LProteinHetionet hetionet:interacts:2257-23327Inferred only
FGF12 interacts with SRPK1ProteinHetionet hetionet:interacts:2257-6732Inferred only
FGF12 interacts with SRPK2ProteinHetionet hetionet:interacts:2257-6733Inferred only
FGF12 participates in Cardiac conductionPathwayReactome R-HSA-5576891Inferred only
FGF12 participates in Embryonic stem cell pluripotency pathwaysPathwayWikiPathways WP3931Inferred only
FGF12 participates in Focal adhesion PI3K Akt mTOR signalingPathwayWikiPathways WP3932Inferred only
FGF12 participates in KCNQ2 and KCNQ3 related epilepsyPathwayWikiPathways WP5599Inferred only
FGF12 participates in MAPK signalingPathwayWikiPathways WP382Inferred only
FGF12 participates in Muscle contractionPathwayReactome R-HSA-397014Inferred only
FGF12 participates in Phase 0 - rapid depolarisationPathwayReactome R-HSA-5576892Inferred only
FGF12 participates in PI3K Akt signalingPathwayWikiPathways WP4172Inferred only
FGF12 participates in Pleural mesotheliomaPathwayWikiPathways WP5087Inferred only
FGF12 participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
FGF12 participates in Sodium channel in epilepsyPathwayWikiPathways WP5598Inferred only
FGF12 regulates regulation of neuronal action potentialBiological processgene ontology P61328|GO:0098908Inferred only
FGF12 regulates regulation of sodium ion transmembrane transportBiological processgene ontology P61328|GO:1902305Inferred only
FGF12 regulates regulation of voltage-gated sodium channel activityBiological processgene ontology P61328|GO:1905150Inferred only

Other names

6 names

Resolves to: FGF12

Also called: FGF-12FGF12BFHF-1FHF1Fibroblast growth factor homologous factor 1Myocyte-activating factor

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