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A reference for what the literature reports. Not medical advice.

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Proteins/UNIPROT:Q8IUE6

H2AC21

Protein·UNIPROT:Q8IUE6

Open in the graph

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Function from UniProtKB (Q8IUE6), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

33 statements

33 statements · 2 reference databases · Subject: H2AC21 · Sources: Hetionet, Reactome

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AEN covaries with H2AC21ProteinHetionet hetionet:covaries:317772-64782Inferred only
CRABP1 covaries with H2AC21ProteinHetionet hetionet:covaries:1381-317772Inferred only
H2AC21 covaries with HJVProteinHetionet hetionet:covaries:148738-317772Inferred only
MYADM covaries with H2AC21ProteinHetionet hetionet:covaries:317772-91663Inferred only
NDST4 covaries with H2AC21ProteinHetionet hetionet:covaries:317772-64579Inferred only
SLC20A1 covaries with H2AC21ProteinHetionet hetionet:covaries:317772-6574Inferred only
APP interacts with H2AC21ProteinHetionet hetionet:interacts:317772-351Inferred only
ARRB1 interacts with H2AC21ProteinHetionet hetionet:interacts:317772-408Inferred only
ARRB2 interacts with H2AC21ProteinHetionet hetionet:interacts:317772-409Inferred only
BARD1 interacts with H2AC21ProteinHetionet hetionet:interacts:317772-580Inferred only
EP300 interacts with H2AC21ProteinHetionet hetionet:interacts:2033-317772Inferred only
HNF1A interacts with H2AC21ProteinHetionet hetionet:interacts:317772-6927Inferred only

Show the remaining 21

UBC interacts with H2AC21ProteinHetionet hetionet:interacts:317772-7316Inferred only
WDR77 interacts with H2AC21ProteinHetionet hetionet:interacts:317772-79084Inferred only
H2AC21 participates in Chromatin modifying enzymesPathwayReactome R-HSA-3247509Inferred only
H2AC21 participates in Chromatin organizationPathwayReactome R-HSA-4839726Inferred only
H2AC21 participates in Dengue Virus InfectionPathwayReactome R-HSA-9839923Inferred only
H2AC21 participates in Dengue Virus-Host InteractionsPathwayReactome R-HSA-9918481Inferred only
H2AC21 participates in DeubiquitinationPathwayReactome R-HSA-5688426Inferred only
H2AC21 participates in DiseasePathwayReactome R-HSA-1643685Inferred only
H2AC21 participates in HATs acetylate histonesPathwayReactome R-HSA-3214847Inferred only
H2AC21 participates in HCMV Early EventsPathwayReactome R-HSA-9609690Inferred only
H2AC21 participates in HCMV InfectionPathwayReactome R-HSA-9609646Inferred only
H2AC21 participates in HCMV Late EventsPathwayReactome R-HSA-9610379Inferred only
H2AC21 participates in HDACs deacetylate histonesPathwayReactome R-HSA-3214815Inferred only
H2AC21 participates in Infectious diseasePathwayReactome R-HSA-5663205Inferred only
H2AC21 participates in Metabolism of proteinsPathwayReactome R-HSA-392499Inferred only
H2AC21 participates in Metalloprotease DUBsPathwayReactome R-HSA-5689901Inferred only
H2AC21 participates in Post-translational protein modificationPathwayReactome R-HSA-597592Inferred only
H2AC21 participates in RMTs methylate histone argininesPathwayReactome R-HSA-3214858Inferred only
H2AC21 participates in Ub-specific processing proteasesPathwayReactome R-HSA-5689880Inferred only
H2AC21 participates in UCH proteinasesPathwayReactome R-HSA-5689603Inferred only
H2AC21 participates in Viral Infection PathwaysPathwayReactome R-HSA-9824446Inferred only

Other names

3 names

Resolves to: H2AC21

Also called: H2A-clustered histone 21HIST2H2ABHistone H2A type 2-B

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