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Proteins/UNIPROT:P54821
Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (By similarity)..
[Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain..
[Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines..
Function from UniProtKB (P54821), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
13 statements
13 statements · 3 reference databases · Subject: PRRX1 · Sources: gene ontology, Hetionet, WikiPathways
4 names
Resolves to: PRRX1