Biological process
negative regulation of excitatory postsynaptic potential
Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.
Definition from the Gene Ontology (GO:0090394), read 2026-09-23. CC BY 4.0.
GO:0090394Gene Ontology
What the reference databases state
Statements
9 statements
9 statements · 1 reference database · Subject: negative regulation of excitatory postsynaptic potential · Sources: gene ontology
- CBLN1 regulates negative regulation of excitatory postsynaptic potentialProteingene ontology P23435|GO:0090394Inferred only
- EIF4A3 regulates negative regulation of excitatory postsynaptic potentialProteingene ontology P38919|GO:0090394Inferred only
- GRM5 regulates negative regulation of excitatory postsynaptic potentialProteingene ontology P41594|GO:0090394Inferred only
- LRRK2 regulates negative regulation of excitatory postsynaptic potentialProteingene ontology Q5S007|GO:0090394Inferred only
- MTMR2 regulates negative regulation of excitatory postsynaptic potentialProteingene ontology Q13614|GO:0090394Inferred only
- NLGN4X regulates negative regulation of excitatory postsynaptic potentialProteingene ontology Q8N0W4|GO:0090394Inferred only
- PRKN regulates negative regulation of excitatory postsynaptic potentialProteingene ontology O60260|GO:0090394Inferred only
- PTEN regulates negative regulation of excitatory postsynaptic potentialProteingene ontology P60484|GO:0090394Inferred only
- TMEM25 regulates negative regulation of excitatory postsynaptic potentialProteingene ontology Q86YD3|GO:0090394Inferred only