Proteins/UNIPROT:Q04609

FOLH1

ProteinUNIPROT:Q04609

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.

Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

Function from UniProtKB (Q04609), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

14 statements

14 statements · 5 reference databases · Subject: FOLH1 · Sources: gene ontology, Hetionet, Reactome, UniProt, WikiPathways

Order

BBX covaries with FOLH1ProteinHetionet hetionet:covaries:2346-56987Inferred only
ZMYM5 covaries with FOLH1ProteinHetionet hetionet:covaries:2346-9205Inferred only
EGR1 interacts with FOLH1ProteinHetionet hetionet:interacts:1958-2346Inferred only
FOLH1 interacts with MTAPProteinHetionet hetionet:interacts:2346-4507Inferred only
FOLH1 interacts with RPS3ProteinHetionet hetionet:interacts:2346-6188Inferred only
FOLH1 participates in Aspartate and asparagine metabolismPathwayReactome R-HSA-8963693Inferred only
FOLH1 participates in Male infertilityPathwayWikiPathways WP4673Inferred only
FOLH1 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
FOLH1 participates in Metabolism of amino acids and derivativesPathwayReactome R-HSA-71291Inferred only
FOLH1 participates in One carbon metabolismPathwayWikiPathways WP241Inferred only
FOLH1 regulates positive regulation of glutamate receptor signaling pathwayBiological processgene ontology Q04609|GO:1900451Inferred only
AFG3L2 increases the expression of FOLH1ProteinHetionet hetionet:regulates:10939-2346Inferred only

Show the remaining 2

ERCC6L increases the expression of FOLH1ProteinHetionet hetionet:regulates:54821-2346Inferred only
FOLH1 requires the cofactor Zn(2+)CompoundUniProt Q04609Inferred only

Other names

16 names

Resolves to: FOLH1

Also called: Cell growth-inhibiting gene 27 proteinFGCPFolate hydrolase 1FOLHFolylpoly-gamma-glutamate carboxypeptidaseGCPIIGlutamate carboxypeptidase IIMembrane glutamate carboxypeptidasemGCPN-acetylated-alpha-linked acidic dipeptidase INAALAD1NAALADase IProstate-specific membrane antigenPSMPSMAPteroylpoly-gamma-glutamate carboxypeptidase

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