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Proteins/UNIPROT:Q6IQ20
D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid. Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity)..
Function from UniProtKB (Q6IQ20), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
26 statements
26 statements · 7 reference databases · Subject: NAPEPLD · Sources: Bgee, gene ontology, Hetionet, Reactome, Rhea, UniProt, WikiPathways
17 reactions
an N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine+wateran N-acylethanolamine+a 1,2-diacyl-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:33159CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+
4 names
Resolves to: NAPEPLD
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45528CC BY 4.0Reference data
N,1,2-tri-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(9Z-octadecenoyl) ethanolamine+1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45532CC BY 4.0Reference data
N-octadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-octadecanoyl ethanolamine+1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45536CC BY 4.0Reference data
N-hexadecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoylethanolamine+1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45540CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine+1-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD or GDPD3 or GDPD1
Reaction pageLeft to rightBalanced
Rhea RHEA:45544CC BY 4.0Reference data
N-tetradecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-tetradecanoylethanolamine+1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45552CC BY 4.0Reference data
N-dodecanoyl-1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine+waterN-dodecanoylethanolamine+1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphate+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45556CC BY 4.0Reference data
N,1-dihexadecanoyl-sn-glycero-3-phosphoethanolamine+waterN-hexadecanoylethanolamine+1-hexadecanoyl-sn-glycero-3-phosphate+hydron
Reaction pageLeft to rightBalanced
Rhea RHEA:45592CC BY 4.0Reference data
N,1-dihexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine+waterCHEBI:72860+N-hexadecanoylethanolamine+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45596CC BY 4.0Reference data
CHEBI:85295+waterCHEBI:85301+CHEBI:72860+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45608CC BY 4.0Reference data
CHEBI:85296+waterCHEBI:85302+CHEBI:72860+hydron
Catalysed by NAPEPLD
Reaction pageLeft to rightBalanced
Rhea RHEA:45612CC BY 4.0Reference data