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Proteins/UNIPROT:Q9HAT2
Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity..
Function from UniProtKB (Q9HAT2), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
12 statements
12 statements · 4 reference databases · Subject: SIAE · Sources: Bgee, gene ontology, Hetionet, Rhea
3 reactions
water+MAM02545cacetate+N-acetyl-beta-neuraminic acid
Catalysed by SIAE
Reaction pageLeft to rightBalancedEC 3.1.1.53cytosol
Human-GEM MAR09515CC BY 4.0Reference data
N-acetyl-9-O-acetylneuraminate+waterN-acetylneuraminate+acetate+hydron
Catalysed by SIAE
Reaction pageLeft to rightBalanced
3 names
Resolves to: SIAE
an Ac-O-9-sialoglycoconjugate+watera sialoglycoconjugate+acetate+hydron
Catalysed by SIAE
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:80763CC BY 4.0Reference data