Pathway
Polo-like kinase mediated events
At mitotic entry, Plk1 phosphorylates and activates Cdc25C phosphatase, whereas it phosphorylates and down-regulates Wee1A. Plk1 also phosphorylates and inhibits Myt1 activity. Cyclin B1-bound Cdc2, which is the target of Cdc25C, Wee1A, and Myt1, functions in a feedback loop and phosphorylates the latter components (Cdc25C, Wee1A, Myt1). The Cdc2- dependent phosphorylation provides docking sites for the polo-box domain of Plk1, thus promoting the Plk1-dependent regulation of these components and, as a result, activation of Cdc2-Cyclin B1.
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PLK1 phosphorylates and activates the transcription factor FOXM1 which stimulates the expression of a number of genes needed for G2/M transition, including PLK1, thereby creating a positive feedback loop.
What the reference databases state
Statements
16 statements
16 statements · 1 reference database · Subject: Polo-like kinase mediated events · Sources: Reactome
- CCNB1 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- CCNB2 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- CDC25A participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- CDC25C participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- CENPF participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- EP300 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- FOXM1 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- LIN37 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- LIN52 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- LIN54 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- LIN9 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- MYBL2 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
Show the remaining 4
- PKMYT1 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- PLK1 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- RBBP4 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only
- WEE1 participates in Polo-like kinase mediated eventsProteinReactome R-HSA-156711Inferred only