Proteins/UNIPROT:Q9H4B8

DPEP3

ProteinUNIPROT:Q9H4B8

Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem. The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide. A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance..

Function from UniProtKB (Q9H4B8), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

9 statements

9 statements · 1 reference database · Subject: DPEP3 · Sources: Hetionet

Order

DPEP3 covaries with BBS4ProteinHetionet hetionet:covaries:585-64180Inferred only
DPEP3 covaries with C4BPBProteinHetionet hetionet:covaries:64180-725Inferred only
DPEP3 covaries with FOXM1ProteinHetionet hetionet:covaries:2305-64180Inferred only
DPEP3 covaries with GTF3C1ProteinHetionet hetionet:covaries:2975-64180Inferred only
DPEP3 covaries with MYO16ProteinHetionet hetionet:covaries:23026-64180Inferred only
RNASE10 covaries with DPEP3ProteinHetionet hetionet:covaries:338879-64180Inferred only
SLC47A1 covaries with DPEP3ProteinHetionet hetionet:covaries:55244-64180Inferred only
DPEP3 covaries with SNX19ProteinHetionet hetionet:covaries:399979-64180Inferred only
WDR62 covaries with DPEP3ProteinHetionet hetionet:covaries:284403-64180Inferred only

Other names

1 name

Resolves to: DPEP3

Also called: Dipeptidase 3

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