Proteins/UNIPROT:P02511

CRYAB

ProteinUNIPROT:P02511

May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome (By similarity)..

Function from UniProtKB (P02511), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

7 rows

cataract 16 multiple types has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0013411Inferred only
early-onset lamellar cataract has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0018611Inferred only
early-onset nuclear cataract has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0020376Inferred only
early-onset posterior polar cataract has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0020378Inferred only
familial isolated dilated cardiomyopathy has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0700335Inferred only
fatal infantile hypertonic myofibrillar myopathy has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0013472Inferred only
myofibrillar myopathy 2 has a germline basis in CRYABDiseaseGenCC HGNC:2389|MONDO:0012130Inferred only

Statements

58 statements

58 statements · 4 reference databases · Subject: CRYAB · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

APP interacts with CRYABProteinHetionet hetionet:interacts:1410-351Inferred only
AVP interacts with CRYABProteinHetionet hetionet:interacts:1410-551Inferred only
CRYAB interacts with BAG3ProteinHetionet hetionet:interacts:1410-9531Inferred only
BCL2 interacts with CRYABProteinHetionet hetionet:interacts:1410-596Inferred only
BCL2L1 interacts with CRYABProteinHetionet hetionet:interacts:1410-598Inferred only
BMPR2 interacts with CRYABProteinHetionet hetionet:interacts:1410-659Inferred only
CAPN3 interacts with CRYABProteinHetionet hetionet:interacts:1410-825Inferred only
CASP3 interacts with CRYABProteinHetionet hetionet:interacts:1410-836Inferred only
CRYAB interacts with CCL22ProteinHetionet hetionet:interacts:1410-6367Inferred only
CCND1 interacts with CRYABProteinHetionet hetionet:interacts:1410-595Inferred only
CDH16 interacts with CRYABProteinHetionet hetionet:interacts:1014-1410Inferred only
CRYAA interacts with CRYABProteinHetionet hetionet:interacts:1409-1410Inferred only

Show the remaining 46

CRYAB interacts with CRYBA1ProteinHetionet hetionet:interacts:1410-1411Inferred only
CRYAB interacts with CRYBB2ProteinHetionet hetionet:interacts:1410-1415Inferred only
CRYAB interacts with CRYGCProteinHetionet hetionet:interacts:1410-1420Inferred only
CRYAB interacts with CRYGDProteinHetionet hetionet:interacts:1410-1421Inferred only
CRYAB interacts with CSProteinHetionet hetionet:interacts:1410-1431Inferred only
CRYAB interacts with CTNNB1ProteinHetionet hetionet:interacts:1410-1499Inferred only
CRYAB interacts with DESProteinHetionet hetionet:interacts:1410-1674Inferred only
CRYAB interacts with EPB41ProteinHetionet hetionet:interacts:1410-2035Inferred only
CRYAB interacts with FCGR2AProteinHetionet hetionet:interacts:1410-2212Inferred only
CRYAB interacts with FGF2ProteinHetionet hetionet:interacts:1410-2247Inferred only
CRYAB interacts with HDAC1ProteinHetionet hetionet:interacts:1410-3065Inferred only
CRYAB interacts with HSPA4ProteinHetionet hetionet:interacts:1410-3308Inferred only
CRYAB interacts with HSPB1ProteinHetionet hetionet:interacts:1410-3315Inferred only
CRYAB interacts with HSPB2ProteinHetionet hetionet:interacts:1410-3316Inferred only
CRYAB interacts with HSPB8ProteinHetionet hetionet:interacts:1410-26353Inferred only
CRYAB interacts with INSProteinHetionet hetionet:interacts:1410-3630Inferred only
CRYAB interacts with LALBAProteinHetionet hetionet:interacts:1410-3906Inferred only
CRYAB interacts with LBHProteinHetionet hetionet:interacts:1410-81606Inferred only
CRYAB interacts with MDH2ProteinHetionet hetionet:interacts:1410-4191Inferred only
CRYAB interacts with MIPProteinHetionet hetionet:interacts:1410-4284Inferred only
CRYAB interacts with NGFProteinHetionet hetionet:interacts:1410-4803Inferred only
CRYAB interacts with PRKAG3ProteinHetionet hetionet:interacts:1410-53632Inferred only
CRYAB interacts with PSMA3ProteinHetionet hetionet:interacts:1410-5684Inferred only
CRYAB interacts with SNCAProteinHetionet hetionet:interacts:1410-6622Inferred only
CRYAB interacts with TP53ProteinHetionet hetionet:interacts:1410-7157Inferred only
CRYAB interacts with TTNProteinHetionet hetionet:interacts:1410-7273Inferred only
CRYAB interacts with UBCProteinHetionet hetionet:interacts:1410-7316Inferred only
CRYAB interacts with UBE2D1ProteinHetionet hetionet:interacts:1410-7321Inferred only
CRYAB interacts with VEGFAProteinHetionet hetionet:interacts:1410-7422Inferred only
CRYAB participates in Cardiomyocyte signaling converging on titinPathwayWikiPathways WP5344Inferred only
CRYAB participates in Cellular response to heat stressPathwayReactome R-HSA-3371556Inferred only
CRYAB participates in Cellular responses to stimuliPathwayReactome R-HSA-8953897Inferred only
CRYAB participates in Cellular responses to stressPathwayReactome R-HSA-2262752Inferred only
CRYAB participates in HSF1-dependent transactivationPathwayReactome R-HSA-3371571Inferred only
CRYAB regulates negative regulation of amyloid fibril formationBiological processgene ontology P02511|GO:1905907Inferred only
CRYAB regulates negative regulation of apoptotic processBiological processgene ontology P02511|GO:0043066Inferred only
CRYAB regulates negative regulation of cell growthBiological processgene ontology P02511|GO:0030308Inferred only
CRYAB regulates negative regulation of DNA-templated transcriptionBiological processgene ontology P02511|GO:0045892Inferred only
CRYAB regulates negative regulation of intracellular transportBiological processgene ontology P02511|GO:0032387Inferred only
CRYAB regulates negative regulation of protein-containing complex assemblyBiological processgene ontology P02511|GO:0031333Inferred only
CRYAB regulates negative regulation of reactive oxygen species metabolic processBiological processgene ontology P02511|GO:2000378Inferred only
CRYAB regulates regulation of programmed cell deathBiological processgene ontology P02511|GO:0043067Inferred only
ARG1 increases the expression of CRYABProteinHetionet hetionet:regulates:383-1410Inferred only
KDELR3 increases the expression of CRYABProteinHetionet hetionet:regulates:11015-1410Inferred only
PRKDC increases the expression of CRYABProteinHetionet hetionet:regulates:5591-1410Inferred only
TRIM13 increases the expression of CRYABProteinHetionet hetionet:regulates:10206-1410Inferred only

Other names

7 names

Resolves to: CRYAB

Also called: Alpha(B)-crystallinCRYA2Heat shock protein beta-5Heat shock protein family B member 5HSPB5Renal carcinoma antigen NY-REN-27Rosenthal fiber component

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