Proteins/UNIPROT:P00540

MOS

ProteinUNIPROT:P00540

Serine/threonine kinase involved in the regulation of MAPK signaling. Is an activator of the ERK1/2 signaling cascade playing an essential role in the stimulation of oocyte maturation..

Function from UniProtKB (P00540), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

oocyte/zygote/embryo maturation arrest 20 has a germline basis in MOSDiseaseGenCC HGNC:7199|MONDO:0957278Inferred only

Statements

21 statements

21 statements · 3 reference databases · Subject: MOS · Sources: gene ontology, Hetionet, WikiPathways

Order

BMPR2 interacts with MOSProteinHetionet hetionet:interacts:4342-659Inferred only
FYN interacts with MOSProteinHetionet hetionet:interacts:2534-4342Inferred only
HSP90AA1 interacts with MOSProteinHetionet hetionet:interacts:3320-4342Inferred only
HSP90AB1 interacts with MOSProteinHetionet hetionet:interacts:3326-4342Inferred only
HSPA1A interacts with MOSProteinHetionet hetionet:interacts:3304-4342Inferred only
HSPA1A interacts with MOSProteinHetionet hetionet:interacts:3303-4342Inferred only
MOS interacts with MYOD1ProteinHetionet hetionet:interacts:4342-4654Inferred only
MOS participates in Pre implantation embryoPathwayWikiPathways WP3527Inferred only
MOS participates in Regulation of actin cytoskeletonPathwayWikiPathways WP51Inferred only
MOS regulates negative regulation of metaphase/anaphase transition of meiotic cell cycleBiological processgene ontology P00540|GO:1902103Inferred only
MOS regulates positive regulation of ERK1 and ERK2 cascadeBiological processgene ontology P00540|GO:0070374Inferred only
MOS regulates positive regulation of MAPK cascadeBiological processgene ontology P00540|GO:0043410Inferred only

Show the remaining 9

MOS increases the expression of CDK5R1ProteinHetionet hetionet:regulates:4342-8851Inferred only
MOS increases the expression of HERC6ProteinHetionet hetionet:regulates:4342-55008Inferred only
MOS increases the expression of MINDY1ProteinHetionet hetionet:regulates:4342-55793Inferred only
MOS decreases the expression of NPTX2ProteinHetionet hetionet:regulates:4342-4885Inferred only
MOS decreases the expression of NUP85ProteinHetionet hetionet:regulates:4342-79902Inferred only
MOS decreases the expression of PHKA1ProteinHetionet hetionet:regulates:4342-5255Inferred only
MOS increases the expression of S100A7ProteinHetionet hetionet:regulates:4342-6278Inferred only
MOS increases the expression of STEAP1ProteinHetionet hetionet:regulates:4342-26872Inferred only
MOS decreases the expression of TXNDC9ProteinHetionet hetionet:regulates:4342-10190Inferred only

Reactions

2 reactions

L-seryl-[protein]+ATP(4-)O-phospho-L-seryl-[protein]+ADP(3-)+hydron
Catalysed by SGK1 or CDC7 or PLK4 or STK25 or CIT or RIOK3 or MAP2K7 or CHEK1 or BCKDK or IKBKB or CASK or AURKA and 347 more alternatives
Reaction pageLeft to right

Other names

3 names

Resolves to: MOS

Also called: c-MosOocyte maturation factor mosProto-oncogene c-Mos

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