Pathway
Acyl chain remodeling of DAG and TAG
Acyl chain remodeling of triacylglycerol (TAG) and diacylglycerol (DAG) progresses through their hydrolysis by patatin-like phospholipase domain-containing proteins 2/3 (PNPLA2/3). DAG is reacylated back to TAG by acylglycerol O-acyltransferase 1/2 (DGAT1/2), while DAG and its hydrolysis product 2-monoacylglycerol (2-MAG) are transacylated back to TAG by PNPLA2/3. In addition, the DAG hydrolysis product 2-MAG is subsequently hydrolyzed to fatty acid and glycerol by monoglyceride lipase (MGLL).
REACT:R-HSA-1482883Reactome
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: Acyl chain remodeling of DAG and TAG · Sources: Reactome
- AWAT2 participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only
- DGAT1 participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only
- DGAT2 participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only
- DGAT2L6 participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only
- MGLL participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only
- PNPLA2 participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only
- PNPLA3 participates in Acyl chain remodeling of DAG and TAGProteinReactome R-HSA-1482883Inferred only