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Proteins/UNIPROT:Q99518
Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation. Specifically catalyzes S-oxygenation of sulfur derived compounds such as thioureas-derived compounds, thioetherorganophosphates to their sulfenic acid. In vitro, catalyzes S-oxygenation of the second-line antitubercular drugs thiacetazone (TAZ) and ethionamide (ETA), forming a sulfinic acid and a carbodiimide via a postulated sulfenic acid intermediate. Also catalyzes S-oxygenation of the thioether-containing organophosphate insecticides, phorate and disulfoton..
Function from UniProtKB (Q99518), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
14 statements
14 statements · 5 reference databases · Subject: FMO2 · Sources: Hetionet, Human-GEM, Reactome, UniProt, WikiPathways
3 reactions
proton+NADPH(4-)+dioxygen+selenomethioninewater+NADP(3-)+MAM02892r
Catalysed by FMO3 or FMO1 or FMO4 or FMO2 or FMO5
Reaction pageLeft to rightBalancedEC 1.14.13.8endoplasmic reticulum
Human-GEM MAR04009CC BY 4.0Reference data
4 names
Resolves to: FMO2
Reaction pageLeft to rightBalancedEC 1.14.13.8cytosol
Human-GEM MAR07138CC BY 4.0Reference data