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Proteins/UNIPROT:Q9Y6M7
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis. Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells..
[Isoform 6]: Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis..
Function from UniProtKB (Q9Y6M7), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
28 statements
28 statements · 6 reference databases · Subject: SLC4A7 · Sources: gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
hydrogencarbonate+sodium(1+)hydrogencarbonate+sodium(1+)
Transported by SLC4A7
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR05432CC BY 4.0Reference data
12 names
Resolves to: SLC4A7
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08076CC BY 4.0Reference data
3hydrogencarbonate+sodium(1+)3hydrogencarbonate+sodium(1+)
Transported by SLC4A7 or SLC4A4 or SLC4A9 or SLC4A5
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR08077CC BY 4.0Reference data
hydrogencarbonate+sodium(1+)hydrogencarbonate+sodium(1+)
Transported by SLC4A7
Reaction pageDirection not assertedBalanced
Rhea RHEA:70267CC BY 4.0Reference data