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Proteins/UNIPROT:P42768
Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria. In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs)..
Function from UniProtKB (P42768), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
94 statements
94 statements · 4 reference databases · Subject: WAS · Sources: gene ontology, Hetionet, Reactome, WikiPathways
3 names
Resolves to: WAS