Proteins/UNIPROT:Q5T0N5

FNBP1L

ProteinUNIPROT:Q5T0N5

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens..

Function from UniProtKB (Q5T0N5), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Statements

18 statements

18 statements · 3 reference databases · Subject: FNBP1L · Sources: gene ontology, Hetionet, Reactome

Order

ACP1 interacts with FNBP1LProteinHetionet hetionet:interacts:52-54874Inferred only
FNBP1L interacts with ATG3ProteinHetionet hetionet:interacts:54874-64422Inferred only
CDC42 interacts with FNBP1LProteinHetionet hetionet:interacts:54874-998Inferred only
SGSM2 interacts with FNBP1LProteinHetionet hetionet:interacts:54874-9905Inferred only
UBC interacts with FNBP1LProteinHetionet hetionet:interacts:54874-7316Inferred only
USP13 interacts with FNBP1LProteinHetionet hetionet:interacts:54874-8975Inferred only
WASL interacts with FNBP1LProteinHetionet hetionet:interacts:54874-8976Inferred only
FNBP1L participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
FNBP1L participates in Clathrin-mediated endocytosisPathwayReactome R-HSA-8856828Inferred only
FNBP1L participates in Membrane TraffickingPathwayReactome R-HSA-199991Inferred only
FNBP1L participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
FNBP1L participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only

Show the remaining 6

FNBP1L participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
FNBP1L participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
FNBP1L participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
FNBP1L participates in Vesicle-mediated transportPathwayReactome R-HSA-5653656Inferred only
FNBP1L regulates positive regulation of filopodium assemblyBiological processgene ontology Q5T0N5|GO:0051491Inferred only
DNTTIP2 decreases the expression of FNBP1LProteinHetionet hetionet:regulates:30836-54874Inferred only

Other names

4 names

Resolves to: FNBP1L

Also called: C1orf39Toca-1TOCA1Transducer of Cdc42-dependent actin assembly protein 1

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