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Proteins/UNIPROT:Q8NF50

DOCK8

Protein·UNIPROT:Q8NF50

Open in the graph

Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC), and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing..

Function from UniProtKB (Q8NF50), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

2 rows

autosomal dominant non-syndromic intellectual disability has a germline basis in DOCK8DiseaseGenCC HGNC:19191|MONDO:0015802Inferred only
combined immunodeficiency due to DOCK8 deficiency has a germline basis in DOCK8DiseaseGenCC HGNC:19191|MONDO:0009478Inferred only

Statements

24 statements

24 statements · 3 reference databases · Subject: DOCK8 · Sources: gene ontology, Hetionet, Reactome

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DOCK8 covaries with CASP4ProteinHetionet hetionet:covaries:81704-837Inferred only
DOCK8 covaries with GPSM3ProteinHetionet hetionet:covaries:63940-81704Inferred only
DOCK8 covaries with HCSTProteinHetionet hetionet:covaries:10870-81704Inferred only
DOCK8 covaries with NUBP2ProteinHetionet hetionet:covaries:10101-81704Inferred only
CDC42 interacts with DOCK8ProteinHetionet hetionet:interacts:81704-998Inferred only
RAC1 interacts with DOCK8ProteinHetionet hetionet:interacts:5879-81704Inferred only
RHOJ interacts with DOCK8ProteinHetionet hetionet:interacts:57381-81704Inferred only
RHOQ interacts with DOCK8ProteinHetionet hetionet:interacts:23433-81704Inferred only
SMAD2 interacts with DOCK8ProteinHetionet hetionet:interacts:4087-81704Inferred only
UBC interacts with DOCK8ProteinHetionet hetionet:interacts:7316-81704Inferred only
DOCK8 participates in CDC42 GTPase cyclePathwayReactome R-HSA-9013148Inferred only
DOCK8 participates in Factors involved in megakaryocyte development and platelet productionPathwayReactome R-HSA-983231Inferred only

Show the remaining 12

DOCK8 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
DOCK8 participates in RAC1 GTPase cyclePathwayReactome R-HSA-9013149Inferred only
DOCK8 participates in RHO GTPase cyclePathwayReactome R-HSA-9012999Inferred only
DOCK8 participates in RHOJ GTPase cyclePathwayReactome R-HSA-9013409Inferred only
DOCK8 participates in Signal TransductionPathwayReactome R-HSA-162582Inferred only
DOCK8 participates in Signaling by Rho GTPasesPathwayReactome R-HSA-194315Inferred only
DOCK8 participates in Signaling by Rho GTPases, Miro GTPases and RHOBTB3PathwayReactome R-HSA-9716542Inferred only
DOCK8 regulates positive regulation of establishment of T cell polarityBiological processgene ontology Q8NF50|GO:1903905Inferred only
DOCK8 regulates positive regulation of GTPase activityBiological processgene ontology Q8NF50|GO:0043547Inferred only
DOCK8 regulates positive regulation of T cell migrationBiological processgene ontology Q8NF50|GO:2000406Inferred only
DOCK8 regulates regulation of Rho protein signal transductionBiological processgene ontology Q8NF50|GO:0035023Inferred only
DOCK8 regulates regulation of small GTPase mediated signal transductionBiological processgene ontology Q8NF50|GO:0051056Inferred only

Other names

1 name

Resolves to: DOCK8

Also called: Dedicator of cytokinesis protein 8

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