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Proteins/UNIPROT:P08567

PLEK

Protein·UNIPROT:P08567

Open in the graph

Major protein kinase C substrate of platelets.

Function from UniProtKB (P08567), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

Statements

22 statements

22 statements · 4 reference databases · Subject: PLEK · Sources: gene ontology, Hetionet, Reactome, WikiPathways

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ACVR1 interacts with PLEKProteinHetionet hetionet:interacts:5341-90Inferred only
PLEK interacts with CAVIN2ProteinHetionet hetionet:interacts:5341-8436Inferred only
INPP5A interacts with PLEKProteinHetionet hetionet:interacts:3632-5341Inferred only
PLEK interacts with TGFBR1ProteinHetionet hetionet:interacts:5341-7046Inferred only
PLEK interacts with UBCProteinHetionet hetionet:interacts:5341-7316Inferred only
PLEK participates in Disorders of mitochondrial homeostatis dynamics protein import and quality controlPathwayWikiPathways WP5504Inferred only
PLEK participates in HemostasisPathwayReactome R-HSA-109582Inferred only
PLEK participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
PLEK participates in Platelet degranulationPathwayReactome R-HSA-114608Inferred only
PLEK participates in Response to elevated platelet cytosolic Ca2+PathwayReactome R-HSA-76005Inferred only
PLEK participates in Serotonin and anxietyPathwayWikiPathways WP3947Inferred only
PLEK participates in Serotonin and anxiety related eventsPathwayWikiPathways WP3944Inferred only

Show the remaining 10

PLEK participates in TYROBP causal network in microgliaPathwayWikiPathways WP3945Inferred only
PLEK regulates negative regulation of calcium-mediated signalingBiological processgene ontology P08567|GO:0050849Inferred only
PLEK regulates negative regulation of G protein-coupled receptor signaling pathwayBiological processgene ontology P08567|GO:0045744Inferred only
PLEK regulates negative regulation of inositol phosphate biosynthetic processBiological processgene ontology P08567|GO:0010920Inferred only
PLEK regulates negative regulation of thrombin-activated receptor signaling pathwayBiological processgene ontology P08567|GO:0070495Inferred only
PLEK regulates positive regulation of actin filament bundle assemblyBiological processgene ontology P08567|GO:0032233Inferred only
PLEK regulates positive regulation of actin filament depolymerizationBiological processgene ontology P08567|GO:0030836Inferred only
PLEK regulates positive regulation of integrin activationBiological processgene ontology P08567|GO:0033625Inferred only
PLEK regulates positive regulation of platelet activationBiological processgene ontology P08567|GO:0010572Inferred only
PLEK regulates regulation of cell diameterBiological processgene ontology P08567|GO:0060305Inferred only

Other names

2 names

Resolves to: PLEK

Also called: P47Platelet 47 kDa protein

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