Proteins/UNIPROT:Q86UX7

FERMT3

ProteinUNIPROT:Q86UX7

Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity)..

Isoform 2 may act as a repressor of NF-kappa-B and apoptosis..

Function from UniProtKB (Q86UX7), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

GenCC submitters' classifications

1 row

leukocyte adhesion deficiency 3 has a germline basis in FERMT3DiseaseGenCC HGNC:23151|MONDO:0013016Inferred only

Statements

20 statements

20 statements · 4 reference databases · Subject: FERMT3 · Sources: gene ontology, Hetionet, Reactome, WikiPathways

Order

FERMT3 covaries with ADSS2ProteinHetionet hetionet:covaries:159-83706Inferred only
EIF5A2 covaries with FERMT3ProteinHetionet hetionet:covaries:56648-83706Inferred only
HNRNPA3 covaries with FERMT3ProteinHetionet hetionet:covaries:220988-83706Inferred only
HNRNPDL covaries with FERMT3ProteinHetionet hetionet:covaries:83706-9987Inferred only
PFDN6 covaries with FERMT3ProteinHetionet hetionet:covaries:10471-83706Inferred only
RPL13 covaries with FERMT3ProteinHetionet hetionet:covaries:6137-83706Inferred only
APP interacts with FERMT3ProteinHetionet hetionet:interacts:351-83706Inferred only
EXOSC10 interacts with FERMT3ProteinHetionet hetionet:interacts:5394-83706Inferred only
ITGA4 interacts with FERMT3ProteinHetionet hetionet:interacts:3676-83706Inferred only
FERMT3 interacts with NAA38ProteinHetionet hetionet:interacts:83706-84316Inferred only
TINF2 interacts with FERMT3ProteinHetionet hetionet:interacts:26277-83706Inferred only
UBC interacts with FERMT3ProteinHetionet hetionet:interacts:7316-83706Inferred only

Show the remaining 8

VCAM1 interacts with FERMT3ProteinHetionet hetionet:interacts:7412-83706Inferred only
FERMT3 participates in HemostasisPathwayReactome R-HSA-109582Inferred only
FERMT3 participates in Leukocyte intrinsic Hippo pathway functionsPathwayWikiPathways WP4542Inferred only
FERMT3 participates in Platelet activation, signaling and aggregationPathwayReactome R-HSA-76002Inferred only
FERMT3 participates in Platelet degranulationPathwayReactome R-HSA-114608Inferred only
FERMT3 participates in Response to elevated platelet cytosolic Ca2+PathwayReactome R-HSA-76005Inferred only
FERMT3 regulates positive regulation of cell migrationBiological processgene ontology Q86UX7|GO:0030335Inferred only
FERMT3 regulates regulation of cell-cell adhesion mediated by integrinBiological processgene ontology Q86UX7|GO:0033632Inferred only

Other names

6 names

Resolves to: FERMT3

Also called: KIND3Kindlin-3MIG2-like proteinMIG2BUnc-112-related protein 2URP2

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